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PRSS12

GENERAL INFORMATION

Gene name

 PRSS12

Gene description

 Protease, serine, 12 (neurotrypsin, motopsin)

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Tissue enhanced (testis, vagina)
FANTOM5:Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues, including brain.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA035054 , HPA035055
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis, vagina)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)

GENE INFORMATION

Gene name

 PRSS12 (HGNC Symbol)

Synonyms

 BSSP-3, MRT1

Description

 Protease, serine, 12 (neurotrypsin, motopsin) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the trypsin family of serine proteases. Studies in mouse suggest that the encoded enzyme may be involved in structural reorganizations associated with learning and memory. The enzyme is also expressed in Leydig cells in the testis, but its function in this tissue is unknown. Defects in this gene are a cause of mental retardation autosomal recessive type 1 (MRT1). [provided by RefSeq, Jul 2010]

Chromosome

 4

Cytoband

 q26

Chromosome location (bp)

 118280038 - 118353003

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164099 (version 83.38)

Entrez gene

 8492

UniProt

 P56730 (UniProt - Evidence at transcript level)

neXtProt

 NX_P56730

Antibodypedia

 PRSS12 antibodies

PROTEIN BROWSER
PRSS12-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRSS12-001
ENSP00000296498
ENST00000296498
P56730 [Direct mapping]
Neurotrypsin
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Enzymes
   Peptidases
   Serine-type peptidases
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
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GO:0004252 [serine-type endopeptidase activity]
GO:0005044 [scavenger receptor activity]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0006887 [exocytosis]
GO:0006898 [receptor-mediated endocytosis]
GO:0008233 [peptidase activity]
GO:0008236 [serine-type peptidase activity]
GO:0016020 [membrane]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031410 [cytoplasmic vesicle]
GO:0031638 [zymogen activation]
GO:0043083 [synaptic cleft]
GO:0043195 [terminal bouton]
GO:0045202 [synapse]
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 875 aa
97.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.