Tissue expression of NPY1R - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	NPY1R
Gene description	Neuropeptide Y receptor Y1
Protein class	G-protein coupled receptors Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (spleen)
GTEx:	Tissue enhanced (spleen)
FANTOM5:	Tissue enhanced (spleen)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen)

GENE INFORMATION
Gene name	NPY1R (HGNC Symbol)
Synonyms	NPYR
Description	Neuropeptide Y receptor Y1 (HGNC Symbol)
Entrez gene summary	This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013]
Chromosome	4
Cytoband	q32.2
Chromosome location (bp)	163323961 - 163344832
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164128 (version 83.38)
Entrez gene	4886
UniProt	P25929 (UniProt - Evidence at protein level)
neXtProt	NX_P25929
Antibodypedia	NPY1R antibodies

PROTEIN BROWSER

NPY1R-001	NPY1R-003	NPY1R-004	NPY1R-005	NPY1R-006	NPY1R-007	NPY1R-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NPY1R-001 ENSP00000354652 ENST00000296533	P25929 [Direct mapping] Neuropeptide Y receptor type 1 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0001601 [peptide YY receptor activity] GO:0001602 [pancreatic polypeptide receptor activity] GO:0003151 [outflow tract morphogenesis] GO:0004930 [G-protein coupled receptor activity] GO:0004983 [neuropeptide Y receptor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006006 [glucose metabolic process] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0007626 [locomotory behavior] GO:0007631 [feeding behavior] GO:0008015 [blood circulation] GO:0008021 [synaptic vesicle] GO:0008217 [regulation of blood pressure] GO:0016021 [integral component of membrane] GO:0019233 [sensory perception of pain] GO:0030424 [axon] GO:0030432 [peristalsis] GO:0032355 [response to estradiol] GO:0040014 [regulation of multicellular organism growth] GO:0045907 [positive regulation of vasoconstriction] GO:0046888 [negative regulation of hormone secretion] GO:0051481 [negative regulation of cytosolic calcium ion concentration] Show all	384 aa 44.4 kDa	No	7
NPY1R-003 ENSP00000427284 ENST00000509586	B4DKL9 [Direct mapping] Neuropeptide Y receptor type 1; cDNA FLJ51985, highly similar to Neuropeptide Y receptor type 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004983 [neuropeptide Y receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0016021 [integral component of membrane] Show all	141 aa 16.6 kDa	No	2
NPY1R-004 ENSP00000427564 ENST00000504790	D6RI97 [Direct mapping] Neuropeptide Y receptor type 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	61 aa 6.6 kDa	No	1
NPY1R-005 ENSP00000426099 ENST00000515701	D6RHH6 [Direct mapping] Neuropeptide Y receptor type 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	60 aa 6.5 kDa	No	1
NPY1R-006 ENSP00000421618 ENST00000512819	D6REY0 [Direct mapping] Neuropeptide Y receptor type 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004983 [neuropeptide Y receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0016021 [integral component of membrane] Show all	99 aa 12 kDa	No	2
NPY1R-007 ENSP00000422963 ENST00000504391	D6R9D0 [Direct mapping] Neuropeptide Y receptor type 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	64 aa 7.6 kDa	No	1
NPY1R-008 ENSP00000423878 ENST00000511901	D6RC44 [Direct mapping] Neuropeptide Y receptor type 1 Show all	Predicted intracellular proteins Show all		25 aa 2.8 kDa	No	0