Cell atlas - ANAPC10 - The Human Protein Atlas

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ANAPC10

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus
	Nucleoplasm

Human cell
	Golgi Apparatus
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ANAPC10
Gene description	Anaphase promoting complex subunit 10
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Golgi apparatus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA044547
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus & nucleoplasm.

Main location

Nucleoplasm (approved), Golgi apparatus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA044547	A-431	Nucleoplasm
	HPA044547	A-431	Golgi apparatus
	HPA044547	U-2 OS	Nucleoplasm
	HPA044547	U-251 MG	Nucleoplasm
	HPA044547	U-251 MG	Golgi apparatus

GENE INFORMATION
Gene name	ANAPC10 (HGNC Symbol)
Synonyms	APC10, DKFZP564L0562, DOC1
Description	Anaphase promoting complex subunit 10 (HGNC Symbol)
Entrez gene summary	ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011]
Chromosome	4
Cytoband	q31.21
Chromosome location (bp)	144967112 - 145098541
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164162 (version 83.38)
Entrez gene	10393
UniProt	Q9UM13 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UM13
Antibodypedia	ANAPC10 antibodies

PROTEIN BROWSER

ANAPC10-001	ANAPC10-002	ANAPC10-003	ANAPC10-004	ANAPC10-013	ANAPC10-014	ANAPC10-015	ANAPC10-016	ANAPC10-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANAPC10-001 ENSP00000310071 ENST00000309439	Q9UM13 [Direct mapping] Anaphase-promoting complex subunit 10 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0005654 [nucleoplasm] GO:0005680 [anaphase-promoting complex] GO:0005829 [cytosol] GO:0007067 [mitotic nuclear division] GO:0007094 [mitotic spindle assembly checkpoint] GO:0030071 [regulation of mitotic metaphase/anaphase transition] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0051301 [cell division] GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0070979 [protein K11-linked ubiquitination] Show all	185 aa 21.3 kDa	No	0
ANAPC10-002 ENSP00000403891 ENST00000451299	Q9UM13 [Direct mapping] Anaphase-promoting complex subunit 10 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0005654 [nucleoplasm] GO:0005680 [anaphase-promoting complex] GO:0005829 [cytosol] GO:0007067 [mitotic nuclear division] GO:0007094 [mitotic spindle assembly checkpoint] GO:0030071 [regulation of mitotic metaphase/anaphase transition] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0051301 [cell division] GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0070979 [protein K11-linked ubiquitination] Show all	185 aa 21.3 kDa	No	0
ANAPC10-003 ENSP00000423995 ENST00000507656	Q9UM13 [Direct mapping] Anaphase-promoting complex subunit 10 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0005654 [nucleoplasm] GO:0005680 [anaphase-promoting complex] GO:0005829 [cytosol] GO:0007067 [mitotic nuclear division] GO:0007094 [mitotic spindle assembly checkpoint] GO:0030071 [regulation of mitotic metaphase/anaphase transition] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0051301 [cell division] GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0070979 [protein K11-linked ubiquitination] Show all	185 aa 21.3 kDa	No	0
ANAPC10-004 ENSP00000423043 ENST00000514390	D6RA92 [Direct mapping] Anaphase-promoting complex subunit 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005680 [anaphase-promoting complex] GO:0030071 [regulation of mitotic metaphase/anaphase transition] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] Show all	158 aa 18 kDa	No	0
ANAPC10-013 ENSP00000421609 ENST00000513054	D6RA92 [Direct mapping] Anaphase-promoting complex subunit 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005680 [anaphase-promoting complex] GO:0030071 [regulation of mitotic metaphase/anaphase transition] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] Show all	158 aa 18 kDa	No	0
ANAPC10-014 ENSP00000424463 ENST00000502847	D6RB36 [Direct mapping] Anaphase-promoting complex subunit 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		68 aa 7.5 kDa	No	0
ANAPC10-015 ENSP00000423223 ENST00000504721	D6R9Q5 [Direct mapping] Anaphase-promoting complex subunit 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		109 aa 12.3 kDa	No	0
ANAPC10-016 ENSP00000425459 ENST00000512680	D6RD74 [Direct mapping] Anaphase-promoting complex subunit 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		126 aa 14.2 kDa	No	0
ANAPC10-201 ENSP00000478501 ENST00000613466	Q9UM13 [Direct mapping] Anaphase-promoting complex subunit 10 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0005654 [nucleoplasm] GO:0005680 [anaphase-promoting complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007067 [mitotic nuclear division] GO:0007094 [mitotic spindle assembly checkpoint] GO:0030071 [regulation of mitotic metaphase/anaphase transition] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0051301 [cell division] GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0070979 [protein K11-linked ubiquitination] Show all	185 aa 21.3 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.