Expression of LSM6 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA045079

GENE INFORMATION
Gene name	LSM6 (HGNC Symbol)
Synonyms	YDR378C
Description	LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated (HGNC Symbol)
Entrez gene summary	Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]
Chromosome	4
Cytoband	q31.22
Chromosome location (bp)	146175685 - 146200000
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164167 (version 83.38)
Entrez gene	11157
UniProt	P62312 (UniProt - Evidence at protein level)
neXtProt	NX_P62312
Antibodypedia	LSM6 antibodies

PROTEIN BROWSER

LSM6-001	LSM6-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LSM6-001 ENSP00000296581 ENST00000296581	P62312 [Direct mapping] U6 snRNA-associated Sm-like protein LSm6 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0000398 [mRNA splicing, via spliceosome] GO:0000932 [cytoplasmic mRNA processing body] GO:0005515 [protein binding] GO:0005681 [spliceosomal complex] GO:0005688 [U6 snRNP] GO:0005730 [nucleolus] GO:0005732 [small nucleolar ribonucleoprotein complex] GO:0005829 [cytosol] GO:0008033 [tRNA processing] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0030490 [maturation of SSU-rRNA] GO:0030532 [small nuclear ribonucleoprotein complex] GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay] GO:0044822 [poly(A) RNA binding] GO:0046540 [U4/U6 x U5 tri-snRNP complex] GO:0070062 [extracellular exosome] Show all	80 aa 9.1 kDa	No	0
LSM6-002 ENSP00000422392 ENST00000502781	P62312 [Direct mapping] U6 snRNA-associated Sm-like protein LSm6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:0000398 [mRNA splicing, via spliceosome] GO:0000932 [cytoplasmic mRNA processing body] GO:0005515 [protein binding] GO:0005681 [spliceosomal complex] GO:0005688 [U6 snRNP] GO:0005730 [nucleolus] GO:0005732 [small nucleolar ribonucleoprotein complex] GO:0005829 [cytosol] GO:0008033 [tRNA processing] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0030490 [maturation of SSU-rRNA] GO:0030532 [small nuclear ribonucleoprotein complex] GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay] GO:0044822 [poly(A) RNA binding] GO:0046540 [U4/U6 x U5 tri-snRNP complex] GO:0070062 [extracellular exosome] Show all	80 aa 9.1 kDa	No	0