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Cancer tissues displayed weak to moderate cytoplasmic and/or membranous positivity. Few cases of renal and pancreatic cancers along with rare case of carcinoid, glioma, colorectal, endometrial, testicular and urothelial cancers were strongly stained. Lymphomas and majority of breast and prostate cancers were negative.
Cancer tissues displayed moderate to strong cytoplasmic and membranous staining. Most of the gliomas, lymphomas, melanomas, renal, prostate and testicular cancers were weakly stained or negative.
Colorectal, endometrial, skin urothelial, pancreatic and liver cancers showed moderate to strong cytoplasmic staining. Most of the remaining cancers were weakly stained or negative.
This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]