Expression of NDUFAF2 in cancer - Summary

CANCER ATLAS

Gene description

NADH dehydrogenase (ubiquinone) complex I, assembly factor 2

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA054776

GENE INFORMATION
Gene name	NDUFAF2 (HGNC Symbol)
Synonyms	B17.2L, mimitin, MMTN, NDUFA12L
Description	NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 (HGNC Symbol)
Entrez gene summary	NADH:ubiquinone oxidoreductase (complex I) catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q) in the first step of the mitochondrial respiratory chain, resulting in the translocation of protons across the inner mitochondrial membrane. This gene encodes a complex I assembly factor. Mutations in this gene cause progressive encephalopathy resulting from mitochondrial complex I deficiency. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q12.1
Chromosome location (bp)	60945129 - 61153037
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164182 (version 83.38)
Entrez gene	91942
UniProt	Q8N183 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N183
Antibodypedia	NDUFAF2 antibodies

PROTEIN BROWSER

NDUFAF2-001	NDUFAF2-003	NDUFAF2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NDUFAF2-001 ENSP00000296597 ENST00000296597	Q8N183 [Direct mapping] Mimitin, mitochondrial Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0008137 [NADH dehydrogenase (ubiquinone) activity] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0045333 [cellular respiration] GO:0061179 [negative regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0072593 [reactive oxygen species metabolic process] Show all	169 aa 19.9 kDa	No	0
NDUFAF2-003 ENSP00000426149 ENST00000502658	H0YA50 [Direct mapping] Mimitin, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		51 aa 6 kDa	No	0
NDUFAF2-004 ENSP00000423377 ENST00000511107	D6RA56 [Direct mapping] Mimitin, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		60 aa 7.1 kDa	No	0