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CMBL

GENERAL INFORMATION

Gene name

 CMBL

Gene description

 Carboxymethylenebutenolidase homolog (Pseudomonas)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA036571
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CMBL (HGNC Symbol)

Synonyms

 FLJ23617

Description

 Carboxymethylenebutenolidase homolog (Pseudomonas) (HGNC Symbol)

Entrez gene summary

 CMBL (EC 3.1.1.45) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the medoxomil moiety is linked to an oxygen atom (Ishizuka et al., 2010 [PubMed 20177059]).[supplied by OMIM, Apr 2010]

Chromosome

 5

Cytoband

 p15.2

Chromosome location (bp)

 10275875 - 10308026

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164237 (version 83.38)

Entrez gene

 134147

UniProt

 Q96DG6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96DG6

Antibodypedia

 CMBL antibodies

PROTEIN BROWSER
CMBL-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CMBL-001
ENSP00000296658
ENST00000296658
Q96DG6 [Direct mapping]
Carboxymethylenebutenolidase homolog
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005829 [cytosol]
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
GO:0070062 [extracellular exosome]
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 245 aa
28 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.