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Malignant cells exhibited weak to moderate cytoplasmic immunoreactivity.
GENE INFORMATION
Gene name
F2RL1 (HGNC Symbol)
Synonyms
GPR11, PAR2
Description
Coagulation factor II (thrombin) receptor-like 1 (HGNC Symbol)
Entrez gene summary
Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence. [provided by RefSeq, Jul 2008]