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This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), or NADH:ubiquinone oxidoreductase, the first multi-subunit enzyme complex of the mitochondrial respiratory chain. Complex I plays a vital role in cellular ATP production, the primary source of energy for many crucial processes in living cells. It removes electrons from NADH and passes them by a series of different protein-coupled redox centers to the electron acceptor ubiquinone. In well-coupled mitochondria, the electron flux leads to ATP generation via the building of a proton gradient across the inner membrane. Complex I is composed of at least 41 subunits, of which 7 are encoded by the mitochondrial genome and the remainder by nuclear genes. [provided by RefSeq, Jul 2008]
O43181 [Direct mapping] NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
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Phobius predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001932 [regulation of protein phosphorylation] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005747 [mitochondrial respiratory chain complex I] GO:0006120 [mitochondrial electron transport, NADH to ubiquinone] GO:0007420 [brain development] GO:0008137 [NADH dehydrogenase (ubiquinone) activity] GO:0016651 [oxidoreductase activity, acting on NAD(P)H] GO:0019933 [cAMP-mediated signaling] GO:0022900 [electron transport chain] GO:0022904 [respiratory electron transport chain] GO:0032981 [mitochondrial respiratory chain complex I assembly] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0045271 [respiratory chain complex I] GO:0045333 [cellular respiration] GO:0048146 [positive regulation of fibroblast proliferation] GO:0051591 [response to cAMP] GO:0072593 [reactive oxygen species metabolic process]
