Tissue expression of ESM1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ESM1
Gene description	Endothelial cell-specific molecule 1
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (thyroid gland, kidney)
GTEx:	Tissue enhanced (lung, kidney)
FANTOM5:	Tissue enhanced (kidney)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (thyroid gland, kidney)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung, kidney)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (kidney)

GENE INFORMATION
Gene name	ESM1
Synonyms
Description	Endothelial cell-specific molecule 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Chromosome	5
Cytoband	q11.2
Chromosome location (bp)	54977864 - 55022671
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164283 (version 83.38)
Entrez gene	11082
UniProt	Q9NQ30 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NQ30
Antibodypedia	ESM1 antibodies

PROTEIN BROWSER

ESM1-001	ESM1-002	ESM1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ESM1-001 ENSP00000370812 ENST00000381405	Q9NQ30 [Direct mapping] Endothelial cell-specific molecule 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0001525 [angiogenesis] GO:0001558 [regulation of cell growth] GO:0002040 [sprouting angiogenesis] GO:0005171 [hepatocyte growth factor receptor binding] GO:0005178 [integrin binding] GO:0005520 [insulin-like growth factor binding] GO:0005576 [extracellular region] GO:0008284 [positive regulation of cell proliferation] GO:1902204 [positive regulation of hepatocyte growth factor receptor signaling pathway] Show all	184 aa 20.1 kDa	Yes	0
ESM1-002 ENSP00000370810 ENST00000381403	Q9NQ30 [Direct mapping] Endothelial cell-specific molecule 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0001525 [angiogenesis] GO:0001558 [regulation of cell growth] GO:0002040 [sprouting angiogenesis] GO:0005171 [hepatocyte growth factor receptor binding] GO:0005178 [integrin binding] GO:0005520 [insulin-like growth factor binding] GO:0005576 [extracellular region] GO:0008284 [positive regulation of cell proliferation] GO:1902204 [positive regulation of hepatocyte growth factor receptor signaling pathway] Show all	134 aa 14.5 kDa	Yes	0
ESM1-004 ENSP00000471642 ENST00000601836	M0R154 [Direct mapping] Endothelial cell-specific molecule 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0001558 [regulation of cell growth] GO:0005520 [insulin-like growth factor binding] GO:0005576 [extracellular region] Show all	89 aa 9.5 kDa	Yes	0