Cell atlas - ARSK - The Human Protein Atlas

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ARSK

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus
	Vesicles

Human cell
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	ARSK
Gene description	Arylsulfatase family, member K
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to vesicles. In addition localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)
Additional location	In addition localized to the Nucleus (approved)
Mouse	Localized to the Vesicles in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA042384
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to vesicles. In addition localized to the nucleus.

Main location

Vesicles (approved)

Additional location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA042384	A-431	Nucleus
	HPA042384	A-431	Vesicles
	HPA042384	PC-3	Nucleoplasm
	HPA042384	PC-3	Vesicles
	HPA042384	U-2 OS	Vesicles

MOUSE CELLS

Main location

Vesicles

Mouse gene

ENSMUSG00000021592 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA042384	NIH 3T3	Vesicles

GENE INFORMATION
Gene name	ARSK (HGNC Symbol)
Synonyms	DKFZp313G1735, TSULF
Description	Arylsulfatase family, member K (HGNC Symbol)
Entrez gene summary	Sulfatases (EC 3.1.5.6), such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]
Chromosome	5
Cytoband	q15
Chromosome location (bp)	95555074 - 95605064
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164291 (version 83.38)
Entrez gene	153642
UniProt	Q6UWY0 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UWY0
Antibodypedia	ARSK antibodies

PROTEIN BROWSER

ARSK-001	ARSK-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARSK-001 ENSP00000369346 ENST00000380009	Q6UWY0 [Direct mapping] Arylsulfatase K Show all	MEMSAT3 predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004065 [arylsulfatase activity] GO:0005576 [extracellular region] GO:0005788 [endoplasmic reticulum lumen] GO:0006665 [sphingolipid metabolic process] GO:0006687 [glycosphingolipid metabolic process] GO:0008152 [metabolic process] GO:0008484 [sulfuric ester hydrolase activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] Show all	536 aa 61.4 kDa	Yes	0
ARSK-003 ENSP00000422126 ENST00000504763	D6R9F9 [Direct mapping] Arylsulfatase K Show all	MEMSAT3 predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		46 aa 4.8 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.