We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia] GO:0001782 [B cell homeostasis] GO:0002020 [protease binding] GO:0004190 [aspartic-type endopeptidase activity] GO:0004197 [cysteine-type endopeptidase activity] GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005123 [death receptor binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006309 [apoptotic DNA fragmentation] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0006974 [cellular response to DNA damage stimulus] GO:0007507 [heart development] GO:0007605 [sensory perception of sound] GO:0007611 [learning or memory] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c] GO:0009411 [response to UV] GO:0009611 [response to wounding] GO:0009749 [response to glucose] GO:0010033 [response to organic substance] GO:0010038 [response to metal ion] GO:0010165 [response to X-ray] GO:0012501 [programmed cell death] GO:0014070 [response to organic cyclic compound] GO:0016005 [phospholipase A2 activator activity] GO:0016485 [protein processing] GO:0021766 [hippocampus development] GO:0022617 [extracellular matrix disassembly] GO:0030182 [neuron differentiation] GO:0030198 [extracellular matrix organization] GO:0030216 [keratinocyte differentiation] GO:0030218 [erythrocyte differentiation] GO:0030220 [platelet formation] GO:0030889 [negative regulation of B cell proliferation] GO:0031264 [death-inducing signaling complex] GO:0032025 [response to cobalt ion] GO:0032355 [response to estradiol] GO:0032403 [protein complex binding] GO:0032496 [response to lipopolysaccharide] GO:0034349 [glial cell apoptotic process] GO:0034612 [response to tumor necrosis factor] GO:0035094 [response to nicotine] GO:0035329 [hippo signaling] GO:0035556 [intracellular signal transduction] GO:0042060 [wound healing] GO:0042493 [response to drug] GO:0042542 [response to hydrogen peroxide] GO:0043029 [T cell homeostasis] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043085 [positive regulation of catalytic activity] GO:0043200 [response to amino acid] GO:0043281 [regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043525 [positive regulation of neuron apoptotic process] GO:0045121 [membrane raft] GO:0045165 [cell fate commitment] GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045786 [negative regulation of cell cycle] GO:0046007 [negative regulation of activated T cell proliferation] GO:0046677 [response to antibiotic] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0051384 [response to glucocorticoid] GO:0051402 [neuron apoptotic process] GO:0071310 [cellular response to organic substance] GO:0071407 [cellular response to organic cyclic compound] GO:0097153 [cysteine-type endopeptidase activity involved in apoptotic process] GO:0097190 [apoptotic signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:0097193 [intrinsic apoptotic signaling pathway] GO:0097194 [execution phase of apoptosis] GO:0097200 [cysteine-type endopeptidase activity involved in execution phase of apoptosis]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004190 [aspartic-type endopeptidase activity] GO:0004197 [cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006309 [apoptotic DNA fragmentation] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c] GO:0012501 [programmed cell death] GO:0022617 [extracellular matrix disassembly] GO:0030182 [neuron differentiation] GO:0030198 [extracellular matrix organization] GO:0030216 [keratinocyte differentiation] GO:0030218 [erythrocyte differentiation] GO:0030220 [platelet formation] GO:0034612 [response to tumor necrosis factor] GO:0035329 [hippo signaling] GO:0043066 [negative regulation of apoptotic process] GO:0043281 [regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0097153 [cysteine-type endopeptidase activity involved in apoptotic process] GO:0097190 [apoptotic signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:0097193 [intrinsic apoptotic signaling pathway] GO:0097194 [execution phase of apoptosis] GO:0097200 [cysteine-type endopeptidase activity involved in execution phase of apoptosis]