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ERAP1

GENERAL INFORMATION

Gene name

 ERAP1

Gene description

 Endoplasmic reticulum aminopeptidase 1

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression with nuclear expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB025095
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ERAP1 (HGNC Symbol)

Synonyms

 A-LAP, ARTS-1, ERAAP1, KIAA0525, PILS-AP

Description

 Endoplasmic reticulum aminopeptidase 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

Chromosome

 5

Cytoband

 q15

Chromosome location (bp)

 96760810 - 96808100

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164307 (version 83.38)

Entrez gene

 51752

UniProt

 Q9NZ08 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NZ08

Antibodypedia

 ERAP1 antibodies

PROTEIN BROWSER
ERAP1-001
ERAP1-002
ERAP1-003
ERAP1-004
ERAP1-005
ERAP1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ERAP1-001
ENSP00000296754
ENST00000296754
Q9NZ08 [Direct mapping]
Endoplasmic reticulum aminopeptidase 1
Show all
Enzymes
   Peptidases
   Metallopeptidases
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0002250 [adaptive immune response]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0004177 [aminopeptidase activity]
GO:0005138 [interleukin-6 receptor binding]
GO:0005151 [interleukin-1, Type II receptor binding]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006509 [membrane protein ectodomain proteolysis]
GO:0008217 [regulation of blood pressure]
GO:0008233 [peptidase activity]
GO:0008235 [metalloexopeptidase activity]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009617 [response to bacterium]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019885 [antigen processing and presentation of endogenous peptide antigen via MHC class I]
GO:0042277 [peptide binding]
GO:0043171 [peptide catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045088 [regulation of innate immune response]
GO:0045444 [fat cell differentiation]
GO:0045766 [positive regulation of angiogenesis]
GO:0070006 [metalloaminopeptidase activity]
GO:0070062 [extracellular exosome]
Show all
 948 aa
107.8 kDa 		Yes 0
ERAP1-002
ENSP00000406304
ENST00000443439
Q9NZ08 [Direct mapping]
Endoplasmic reticulum aminopeptidase 1
Show all
Enzymes
   Peptidases
   Metallopeptidases
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0002250 [adaptive immune response]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0004177 [aminopeptidase activity]
GO:0005138 [interleukin-6 receptor binding]
GO:0005151 [interleukin-1, Type II receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006509 [membrane protein ectodomain proteolysis]
GO:0008217 [regulation of blood pressure]
GO:0008235 [metalloexopeptidase activity]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009617 [response to bacterium]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019885 [antigen processing and presentation of endogenous peptide antigen via MHC class I]
GO:0042277 [peptide binding]
GO:0043171 [peptide catabolic process]
GO:0045088 [regulation of innate immune response]
GO:0045444 [fat cell differentiation]
GO:0070006 [metalloaminopeptidase activity]
GO:0070062 [extracellular exosome]
Show all
 941 aa
107.2 kDa 		Yes 0
ERAP1-003
ENSP00000421697
ENST00000507154
D6RAL9 [Direct mapping]
Endoplasmic reticulum aminopeptidase 1
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
Show all
 129 aa
14.6 kDa 		Yes 0
ERAP1-004
ENSP00000422631
ENST00000508227
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 9 aa
1.1 kDa 		No 0
ERAP1-005
ENSP00000427025
ENST00000503921
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 1 aa
0.1 kDa 		No 0
ERAP1-008
ENSP00000425381
ENST00000512852
H0Y9X5 [Direct mapping]
Endoplasmic reticulum aminopeptidase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006508 [proteolysis]
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 144 aa
16.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.