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RPTOR independent companion of MTOR, complex 2 (HGNC Symbol)
Entrez gene summary
RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]
Q6R327 [Direct mapping] Rapamycin-insensitive companion of mTOR
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MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005488 [binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008047 [enzyme activator activity] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009790 [embryo development] GO:0018105 [peptidyl-serine phosphorylation] GO:0019901 [protein kinase binding] GO:0030010 [establishment of cell polarity] GO:0030950 [establishment or maintenance of actin cytoskeleton polarity] GO:0031295 [T cell costimulation] GO:0031532 [actin cytoskeleton reorganization] GO:0031929 [TOR signaling] GO:0031932 [TORC2 complex] GO:0032008 [positive regulation of TOR signaling] GO:0032956 [regulation of actin cytoskeleton organization] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042325 [regulation of phosphorylation] GO:0043085 [positive regulation of catalytic activity] GO:0045087 [innate immune response] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0051896 [regulation of protein kinase B signaling] GO:0051897 [positive regulation of protein kinase B signaling]