Cell atlas - KLKB1 - The Human Protein Atlas

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KLKB1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	KLKB1
Gene description	Kallikrein B, plasma (Fletcher factor) 1
Protein class	Disease related genes Enzymes FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (NTERA-2, SCLC-21H)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (NTERA-2, SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	KLKB1 (HGNC Symbol)
Synonyms	KLK3
Description	Kallikrein B, plasma (Fletcher factor) 1 (HGNC Symbol)
Entrez gene summary	Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q35.2
Chromosome location (bp)	186208979 - 186258471
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164344 (version 83.38)
Entrez gene	3818
UniProt	P03952 (UniProt - Evidence at protein level)
neXtProt	NX_P03952
Antibodypedia	KLKB1 antibodies

PROTEIN BROWSER

KLKB1-001	KLKB1-002	KLKB1-003	KLKB1-004	KLKB1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KLKB1-001 ENSP00000264690 ENST00000264690	P03952 [Direct mapping] Plasma kallikrein Plasma kallikrein heavy chain Plasma kallikrein light chain Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002542 [Factor XII activation] GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0007596 [blood coagulation] GO:0007597 [blood coagulation, intrinsic pathway] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0031638 [zymogen activation] GO:0031639 [plasminogen activation] GO:0042730 [fibrinolysis] GO:0051919 [positive regulation of fibrinolysis] GO:0070062 [extracellular exosome] GO:0097421 [liver regeneration] Show all	638 aa 71.3 kDa	Yes	0
KLKB1-002 ENSP00000412366 ENST00000428196	C9J075 [Direct mapping] Plasma kallikrein Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006508 [proteolysis] Show all	148 aa 16.6 kDa	Yes	0
KLKB1-003 ENSP00000424469 ENST00000513864	E9PBC5 [Direct mapping] Plasma kallikrein Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006508 [proteolysis] Show all	514 aa 57.6 kDa	No	0
KLKB1-004 ENSP00000415563 ENST00000446598	C9JCT1 [Direct mapping] Plasma kallikrein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006508 [proteolysis] Show all	141 aa 15.9 kDa	No	0
KLKB1-008 ENSP00000426629 ENST00000511608	H0YAC1 [Direct mapping] Plasma kallikrein Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0004497 [monooxygenase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006508 [proteolysis] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	686 aa 76.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.