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GDF9

GENERAL INFORMATION

Gene name

 GDF9

Gene description

 Growth differentiation factor 9

Protein class

 Disease related genes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (testis, epididymis)
GTEx:Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Expression in ovarian follicles.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Supported based on 1 antibody.
HPA069146
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Ovary

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (testis, epididymis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)

GENE INFORMATION

Gene name

 GDF9

Synonyms

Description

 Growth differentiation factor 9 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the transforming growth factor-beta superfamily. The encoded preproprotein is processed into a secreted factor that is required for ovarian folliculogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Chromosome

 5

Cytoband

 q31.1

Chromosome location (bp)

 132861181 - 132866884

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164404 (version 83.38)

Entrez gene

 2661

UniProt

 O60383 (UniProt - Evidence at protein level)

neXtProt

 NX_O60383

Antibodypedia

 GDF9 antibodies

PROTEIN BROWSER
GDF9-001
GDF9-201
GDF9-202
GDF9-203
GDF9-204

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GDF9-001
ENSP00000367942
ENST00000378673
O60383 [Direct mapping]
Growth/differentiation factor 9
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Show all
GO:0001555 [oocyte growth]
GO:0005125 [cytokine activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007292 [female gamete generation]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0030308 [negative regulation of cell growth]
GO:0030509 [BMP signaling pathway]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048468 [cell development]
GO:0060395 [SMAD protein signal transduction]
GO:2000870 [regulation of progesterone secretion]
Show all
 454 aa
51.4 kDa 		Yes 0
GDF9-201
ENSP00000296875
ENST00000296875
B4DXG3 [Direct mapping]
Growth/differentiation factor 9; cDNA FLJ53899, highly similar to Growth/differentiation factor 9; cDNA, FLJ78872, highly similar to Growth/differentiation factor 9
Show all
Predicted intracellular proteins
Show all
GO:0005125 [cytokine activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005615 [extracellular space]
GO:0008083 [growth factor activity]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0030509 [BMP signaling pathway]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048468 [cell development]
GO:0060395 [SMAD protein signal transduction]
Show all
 366 aa
41.8 kDa 		No 0
GDF9-202
ENSP00000484339
ENST00000621295
B4DXG3 [Direct mapping]
Growth/differentiation factor 9; cDNA FLJ53899, highly similar to Growth/differentiation factor 9; cDNA, FLJ78872, highly similar to Growth/differentiation factor 9
Show all
Predicted intracellular proteins
Show all
GO:0005125 [cytokine activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005615 [extracellular space]
GO:0008083 [growth factor activity]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0030509 [BMP signaling pathway]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048468 [cell development]
GO:0060395 [SMAD protein signal transduction]
Show all
 366 aa
41.8 kDa 		No 0
GDF9-203
ENSP00000485037
ENST00000624492
B4DXG3 [Direct mapping]
Growth/differentiation factor 9; cDNA FLJ53899, highly similar to Growth/differentiation factor 9; cDNA, FLJ78872, highly similar to Growth/differentiation factor 9
Show all
Predicted intracellular proteins
Show all
GO:0005125 [cytokine activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005615 [extracellular space]
GO:0008083 [growth factor activity]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0030509 [BMP signaling pathway]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048468 [cell development]
GO:0060395 [SMAD protein signal transduction]
Show all
 366 aa
41.8 kDa 		No 0
GDF9-204
ENSP00000485231
ENST00000624495
B4DXG3 [Direct mapping]
Growth/differentiation factor 9; cDNA FLJ53899, highly similar to Growth/differentiation factor 9; cDNA, FLJ78872, highly similar to Growth/differentiation factor 9
Show all
Predicted intracellular proteins
Show all
GO:0005125 [cytokine activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005615 [extracellular space]
GO:0008083 [growth factor activity]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0030509 [BMP signaling pathway]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048468 [cell development]
GO:0060395 [SMAD protein signal transduction]
Show all
 366 aa
41.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.