Cell atlas - TLX3 - The Human Protein Atlas

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TLX3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Centrosome
	Nucleoplasm

Human cell
	Centrosome
	Nucleoplasm

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GENERAL INFORMATION
Gene name	TLX3
Gene description	T-cell leukemia homeobox 3
Protein class	Cancer-related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the centrosome & nucleoplasm.
RNA cell category	Cell line enriched (SH-SY5Y)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Centrosome (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA074512
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (SH-SY5Y) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the centrosome & nucleoplasm.

Main location

Nucleoplasm (approved), Centrosome (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA074512	HeLa	Nucleoplasm
	HPA074512	HeLa	Centrosome
	HPA074512	SH-SY5Y	Nucleus
	HPA074512	SH-SY5Y	Centrosome
	HPA074512	U-2 OS	Nucleoplasm
	HPA074512	U-2 OS	Centrosome

GENE INFORMATION
Gene name	TLX3 (HGNC Symbol)
Synonyms	HOX11L2, RNX
Description	T-cell leukemia homeobox 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an orphan homeobox protein that encodes a DNA-binding nuclear transcription factor. A translocation [t(5;14)(q35;q32)] involving this gene is associated with T-cell acute lymphoblastic leukemia (T-ALL) in children and young adults. [provided by RefSeq, Nov 2015]
Chromosome	5
Cytoband	q35.1
Chromosome location (bp)	171309284 - 171312134
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164438 (version 83.38)
Entrez gene	30012
UniProt	O43711 (UniProt - Evidence at protein level)
neXtProt	NX_O43711
Antibodypedia	TLX3 antibodies

PROTEIN BROWSER

TLX3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TLX3-001 ENSP00000296921 ENST00000296921	O43711 [Direct mapping] T-cell leukemia homeobox protein 3 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0001708 [cell fate specification] GO:0001764 [neuron migration] GO:0002087 [regulation of respiratory gaseous exchange by neurological system process] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0007417 [central nervous system development] GO:0007585 [respiratory gaseous exchange] GO:0030182 [neuron differentiation] GO:0043565 [sequence-specific DNA binding] GO:0045665 [negative regulation of neuron differentiation] GO:0048665 [neuron fate specification] Show all	291 aa 31.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.