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The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
Predicted intracellular proteins Transcription factors Immunoglobulin fold Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000785 [chromatin] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001191 [transcriptional repressor activity, RNA polymerase II transcription factor binding] GO:0001570 [vasculogenesis] GO:0001756 [somitogenesis] GO:0001839 [neural plate morphogenesis] GO:0001843 [neural tube closure] GO:0003007 [heart morphogenesis] GO:0003257 [positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007341 [penetration of zona pellucida] GO:0007498 [mesoderm development] GO:0007509 [mesoderm migration involved in gastrulation] GO:0008284 [positive regulation of cell proliferation] GO:0008595 [anterior/posterior axis specification, embryo] GO:0009653 [anatomical structure morphogenesis] GO:0009952 [anterior/posterior pattern specification] GO:0014028 [notochord formation] GO:0022414 [reproductive process] GO:0023019 [signal transduction involved in regulation of gene expression] GO:0030509 [BMP signaling pathway] GO:0030903 [notochord development] GO:0036342 [post-anal tail morphogenesis] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048706 [embryonic skeletal system development] GO:0060070 [canonical Wnt signaling pathway] GO:0060349 [bone morphogenesis] GO:0060395 [SMAD protein signal transduction] GO:0061371 [determination of heart left/right asymmetry] GO:0071300 [cellular response to retinoic acid] GO:0090009 [primitive streak formation]