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Gene name

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Chromosome

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Reliability

Reliability

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Validation

Method

Validation

Method

Validation

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Searches

Tissue

Cell type

Expression

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Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

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Score

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Antibodies

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T
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

T

Gene description

T brachyury transcription factor

Protein class

Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (parathyroid gland)
GTEx:Tissue enhanced (pituitary gland)
FANTOM5:Tissue enhanced (pituitary gland)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

Uncertain based on 1 antibody.
HPA003322
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
N/A
Cerebral cortex
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Thyroid gland
N/A
Parathyroid gland
N/A
Adrenal gland
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Bone marrow
N/A
Lymph node
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Heart muscle
N/A
Skeletal muscle
N/A
Smooth muscle
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Gallbladder
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Salivary gland
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Small intestine
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
Prostate
N/A
Seminal vesicle
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
Endometrium
N/A
Fallopian tube
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Adipose tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Rectum

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (parathyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (pituitary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (pituitary gland)

GENE INFORMATION

Gene name

T

Synonyms

Description

T brachyury transcription factor (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

Chromosome

6

Cytoband

q27

Chromosome location (bp)

166157656 - 166168700

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000164458 (version 83.38)

Entrez gene

6862

UniProt

O15178 (UniProt - Evidence at protein level)

neXtProt

NX_O15178

Antibodypedia

T antibodies

PROTEIN BROWSER

T-001
T-002
T-003
T-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

T-001
ENSP00000296946
ENST00000296946
O15178 [Direct mapping]
Brachyury protein
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000785 [chromatin]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001191 [transcriptional repressor activity, RNA polymerase II transcription factor binding]
GO:0001570 [vasculogenesis]
GO:0001756 [somitogenesis]
GO:0001839 [neural plate morphogenesis]
GO:0001843 [neural tube closure]
GO:0003007 [heart morphogenesis]
GO:0003257 [positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007341 [penetration of zona pellucida]
GO:0007498 [mesoderm development]
GO:0007509 [mesoderm migration involved in gastrulation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008595 [anterior/posterior axis specification, embryo]
GO:0009653 [anatomical structure morphogenesis]
GO:0009952 [anterior/posterior pattern specification]
GO:0014028 [notochord formation]
GO:0022414 [reproductive process]
GO:0023019 [signal transduction involved in regulation of gene expression]
GO:0030509 [BMP signaling pathway]
GO:0030903 [notochord development]
GO:0036342 [post-anal tail morphogenesis]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048706 [embryonic skeletal system development]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060349 [bone morphogenesis]
GO:0060395 [SMAD protein signal transduction]
GO:0061371 [determination of heart left/right asymmetry]
GO:0071300 [cellular response to retinoic acid]
GO:0090009 [primitive streak formation]
Show all
435 aa
47.4 kDa
No 0
T-002
ENSP00000355836
ENST00000366871
O15178 [Direct mapping]
Brachyury protein
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001191 [transcriptional repressor activity, RNA polymerase II transcription factor binding]
GO:0003007 [heart morphogenesis]
GO:0003257 [positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007498 [mesoderm development]
GO:0008595 [anterior/posterior axis specification, embryo]
GO:0090009 [primitive streak formation]
Show all
377 aa
41.1 kDa
No 0
T-003
ENSP00000355841
ENST00000366876
J3KP65 [Direct mapping]
Brachyury protein; T, brachyury homolog (Mouse), isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
404 aa
44.2 kDa
No 0
T-004
ENSP00000453512
ENST00000461348
H0YM91 [Direct mapping]
Brachyury protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
243 aa
27.4 kDa
No 0

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