Cell atlas - PDSS2 - The Human Protein Atlas

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PDSS2

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	PDSS2
Gene description	Prenyl (decaprenyl) diphosphate synthase, subunit 2
Protein class	Cancer-related genes Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA029685 , HPA029686
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA029685	A-431	No staining
	HPA029685	U-2 OS	Cytosol
	HPA029685	U-251 MG	Cytosol
	HPA029686	A-431	Cytosol
	HPA029686	U-2 OS	Cytosol
	HPA029686	U-251 MG	Cytosol

GENE INFORMATION
Gene name	PDSS2 (HGNC Symbol)
Synonyms	bA59I9.3, C6orf210
Description	Prenyl (decaprenyl) diphosphate synthase, subunit 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an enzyme that synthesizes the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. Defects in this gene are a cause of coenzyme Q10 deficiency.[provided by RefSeq, Oct 2009]
Chromosome	6
Cytoband	q21
Chromosome location (bp)	107152557 - 107459564
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164494 (version 83.38)
Entrez gene	57107
UniProt	Q86YH6 (UniProt - Evidence at protein level)
neXtProt	NX_Q86YH6
Antibodypedia	PDSS2 antibodies

PROTEIN BROWSER

PDSS2-001	PDSS2-002	PDSS2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PDSS2-001 ENSP00000358033 ENST00000369037	Q86YH6 [Direct mapping] Decaprenyl-diphosphate synthase subunit 2 Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000010 [trans-hexaprenyltranstransferase activity] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006744 [ubiquinone biosynthetic process] GO:0008299 [isoprenoid biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0046982 [protein heterodimerization activity] GO:0050347 [trans-octaprenyltranstransferase activity] GO:0050878 [regulation of body fluid levels] GO:0051290 [protein heterotetramerization] GO:1990234 [transferase complex] Show all	399 aa 44.1 kDa	No	0
PDSS2-002 ENSP00000358027 ENST00000369031	Q86YH6 [Direct mapping] Decaprenyl-diphosphate synthase subunit 2 Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000010 [trans-hexaprenyltranstransferase activity] GO:0005737 [cytoplasm] GO:0005759 [mitochondrial matrix] GO:0006744 [ubiquinone biosynthetic process] GO:0008299 [isoprenoid biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0046982 [protein heterodimerization activity] GO:1990234 [transferase complex] Show all	240 aa 26.4 kDa	No	0
PDSS2-003 ENSP00000392613 ENST00000449027	Q5JRD6 [Direct mapping] Decaprenyl-diphosphate synthase subunit 2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		80 aa 9.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.