Cell atlas - STXBP5 - The Human Protein Atlas

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STXBP5

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	STXBP5
Gene description	Syntaxin binding protein 5 (tomosyn)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (HMC-1, HEL)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA039991 , HPA049727
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HMC-1, HEL) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA039991	A-431	Cytosol
	HPA039991	U-2 OS	Cytosol
	HPA039991	U-251 MG	Cytosol
	HPA049727	A-431	Cytosol
	HPA049727	U-2 OS	Cytosol
	HPA049727	U-251 MG	Cytosol

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000019790 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA049727	NIH 3T3	No staining

GENE INFORMATION
Gene name	STXBP5 (HGNC Symbol)
Synonyms	LLGL3, tomosyn
Description	Syntaxin binding protein 5 (tomosyn) (HGNC Symbol)
Entrez gene summary	Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by stimulating SNARE complex formation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	q24.3
Chromosome location (bp)	147204425 - 147390476
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164506 (version 83.38)
Entrez gene	134957
UniProt	Q5T5C0 (UniProt - Evidence at protein level)
neXtProt	NX_Q5T5C0
Antibodypedia	STXBP5 antibodies

PROTEIN BROWSER

STXBP5-001	STXBP5-002	STXBP5-003	STXBP5-004	STXBP5-005	STXBP5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STXBP5-001 ENSP00000356451 ENST00000367481	Q5T5C0 [Direct mapping] Syntaxin-binding protein 5 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005892 [acetylcholine-gated channel complex] GO:0008021 [synaptic vesicle] GO:0010468 [regulation of gene expression] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] GO:0016192 [vesicle-mediated transport] GO:0017075 [syntaxin-1 binding] GO:0017137 [Rab GTPase binding] GO:0017157 [regulation of exocytosis] GO:0019905 [syntaxin binding] GO:0030054 [cell junction] GO:0030141 [secretory granule] GO:0030193 [regulation of blood coagulation] GO:0030659 [cytoplasmic vesicle membrane] GO:0031201 [SNARE complex] GO:0043547 [positive regulation of GTPase activity] GO:0045921 [positive regulation of exocytosis] GO:0050708 [regulation of protein secretion] Show all	1115 aa 123.5 kDa	No	0
STXBP5-002 ENSP00000321826 ENST00000321680	Q5T5C0 [Direct mapping] Syntaxin-binding protein 5 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005892 [acetylcholine-gated channel complex] GO:0006887 [exocytosis] GO:0008021 [synaptic vesicle] GO:0010468 [regulation of gene expression] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] GO:0016192 [vesicle-mediated transport] GO:0017075 [syntaxin-1 binding] GO:0017137 [Rab GTPase binding] GO:0017157 [regulation of exocytosis] GO:0019905 [syntaxin binding] GO:0030054 [cell junction] GO:0030141 [secretory granule] GO:0030193 [regulation of blood coagulation] GO:0030659 [cytoplasmic vesicle membrane] GO:0031201 [SNARE complex] GO:0043547 [positive regulation of GTPase activity] GO:0045921 [positive regulation of exocytosis] GO:0050708 [regulation of protein secretion] Show all	1151 aa 127.6 kDa	No	0
STXBP5-003 ENSP00000356450 ENST00000367480	Q5T5C0 [Direct mapping] Syntaxin-binding protein 5 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005892 [acetylcholine-gated channel complex] GO:0008021 [synaptic vesicle] GO:0010468 [regulation of gene expression] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] GO:0016192 [vesicle-mediated transport] GO:0017075 [syntaxin-1 binding] GO:0017137 [Rab GTPase binding] GO:0017157 [regulation of exocytosis] GO:0019905 [syntaxin binding] GO:0030054 [cell junction] GO:0030141 [secretory granule] GO:0030193 [regulation of blood coagulation] GO:0030659 [cytoplasmic vesicle membrane] GO:0031201 [SNARE complex] GO:0043547 [positive regulation of GTPase activity] GO:0045921 [positive regulation of exocytosis] GO:0050708 [regulation of protein secretion] Show all	1098 aa 121.6 kDa	No	0
STXBP5-004 ENSP00000376112 ENST00000392291	Q5JRH0 [Direct mapping] Syntaxin-binding protein 5 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	264 aa 29.1 kDa	No	0
STXBP5-005 ENSP00000356445 ENST00000367475	H0Y332 [Direct mapping] Syntaxin-binding protein 5 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		174 aa 18.8 kDa	No	0
STXBP5-201 ENSP00000441479 ENST00000546097	Q3B794 [Direct mapping] STXBP5 protein; Syntaxin-binding protein 5 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	308 aa 34.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.