Expression of HIST1H2AA in cancer - Summary

CANCER ATLAS

Gene description

Histone cluster 1, H2aa

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA041189

GENE INFORMATION
Gene name	HIST1H2AA (HGNC Symbol)
Synonyms	bA317E16.2, H2AFR
Description	Histone cluster 1, H2aa (HGNC Symbol)
Entrez gene summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]
Chromosome	6
Cytoband	p22.2
Chromosome location (bp)	25726132 - 25726527
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164508 (version 83.38)
Entrez gene	221613
UniProt	Q96QV6 (UniProt - Evidence at protein level)
neXtProt	NX_Q96QV6
Antibodypedia	HIST1H2AA antibodies

PROTEIN BROWSER

HIST1H2AA-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HIST1H2AA-001 ENSP00000297012 ENST00000297012	Q96QV6 [Direct mapping] Histone H2A type 1-A Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Show all	GO:0000784 [nuclear chromosome, telomeric region] GO:0000786 [nucleosome] GO:0000790 [nuclear chromatin] GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006325 [chromatin organization] GO:0006342 [chromatin silencing] GO:0046982 [protein heterodimerization activity] GO:0070062 [extracellular exosome] Show all	131 aa 14.2 kDa	No	0