Expression of PI16 in cancer - Summary - The Human Protein Atlas

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PI16

TISSUE

CELL

CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

CANCER ATLAS

Gene description

Peptidase inhibitor 16

Protein class

Plasma proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA043763

Tissue	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Tissue	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Most liver cancers along with several gliomas, cervical, thyroid, testicular, renal and gastric cancers showed moderate to strong cytoplasmic positivity. Remaining cancer tissues were weakly stained or negative.

GENE INFORMATION
Gene name	PI16 (HGNC Symbol)
Synonyms	CD364, dJ90K10.5, MGC45378, MSMBBP
Description	Peptidase inhibitor 16 (HGNC Symbol)
Entrez gene summary
Chromosome	6
Cytoband	p21.2
Chromosome location (bp)	36948263 - 36964837
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164530 (version 83.38)
Entrez gene	221476
UniProt	Q6UXB8 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UXB8
Antibodypedia	PI16 antibodies

PROTEIN BROWSER

PI16-001	PI16-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PI16-001 ENSP00000362778 ENST00000373674	Q6UXB8 [Direct mapping] Peptidase inhibitor 16 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0010466 [negative regulation of peptidase activity] GO:0016021 [integral component of membrane] GO:0030414 [peptidase inhibitor activity] GO:0061052 [negative regulation of cell growth involved in cardiac muscle cell development] GO:0070062 [extracellular exosome] Show all	463 aa 49.5 kDa	Yes	1
PI16-201 ENSP00000478888 ENST00000611814	Q6UXB8 [Direct mapping] Peptidase inhibitor 16 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0010466 [negative regulation of peptidase activity] GO:0016021 [integral component of membrane] GO:0030414 [peptidase inhibitor activity] GO:0070062 [extracellular exosome] Show all	463 aa 49.5 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.