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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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PI16
  • TISSUE

  • CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

Peptidase inhibitor 16

Protein class

Plasma proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA043763

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most liver cancers along with several gliomas, cervical, thyroid, testicular, renal and gastric cancers showed moderate to strong cytoplasmic positivity. Remaining cancer tissues were weakly stained or negative.

GENE INFORMATION

Gene name

PI16 (HGNC Symbol)

Synonyms

CD364, dJ90K10.5, MGC45378, MSMBBP

Description

Peptidase inhibitor 16 (HGNC Symbol)

Entrez gene summary

Chromosome

6

Cytoband

p21.2

Chromosome location (bp)

36948263 - 36964837

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000164530 (version 83.38)

Entrez gene

221476

UniProt

Q6UXB8 (UniProt - Evidence at protein level)

neXtProt

NX_Q6UXB8

Antibodypedia

PI16 antibodies

PROTEIN BROWSER

PI16-001
PI16-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PI16-001
ENSP00000362778
ENST00000373674
Q6UXB8 [Direct mapping]
Peptidase inhibitor 16
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0010466 [negative regulation of peptidase activity]
GO:0016021 [integral component of membrane]
GO:0030414 [peptidase inhibitor activity]
GO:0061052 [negative regulation of cell growth involved in cardiac muscle cell development]
GO:0070062 [extracellular exosome]
Show all
463 aa
49.5 kDa
Yes 1
PI16-201
ENSP00000478888
ENST00000611814
Q6UXB8 [Direct mapping]
Peptidase inhibitor 16
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0010466 [negative regulation of peptidase activity]
GO:0016021 [integral component of membrane]
GO:0030414 [peptidase inhibitor activity]
GO:0070062 [extracellular exosome]
Show all
463 aa
49.5 kDa
Yes 1

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The Human Protein Atlas project is funded
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