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SLU7

GENERAL INFORMATION

Gene name

 SLU7

Gene description

 SLU7 homolog, splicing factor

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA035907
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin0102030405060TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin05101520RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina020406080Tags Per Million

GENE INFORMATION

Gene name

 SLU7 (HGNC Symbol)

Synonyms

 9G8

Description

 SLU7 homolog, splicing factor (HGNC Symbol)

Entrez gene summary

 Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q33.3

Chromosome location (bp)

 160401641 - 160421711

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164609 (version 83.38)

Entrez gene

 10569

UniProt

 O95391 (UniProt - Evidence at protein level)

neXtProt

 NX_O95391

Antibodypedia

 SLU7 antibodies

PROTEIN BROWSER
SLU7-001
SLU7-002
SLU7-003
SLU7-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLU7-001
ENSP00000297151
ENST00000297151
O95391 [Direct mapping]
Pre-mRNA-splicing factor SLU7
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000380 [alternative mRNA splicing, via spliceosome]
GO:0000386 [second spliceosomal transesterification activity]
GO:0000389 [mRNA 3'-splice site recognition]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0006886 [intracellular protein transport]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0016607 [nuclear speck]
GO:0030532 [small nuclear ribonucleoprotein complex]
GO:0030628 [pre-mRNA 3'-splice site binding]
GO:0034605 [cellular response to heat]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0071013 [catalytic step 2 spliceosome]
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 586 aa
68.4 kDa 		No 0
SLU7-002
ENSP00000428362
ENST00000520664
A0A0C4DGD2 [Direct mapping]
Pre-mRNA-splicing factor SLU7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 101 aa
11.6 kDa 		No 0
SLU7-003
ENSP00000429990
ENST00000519349
E5RGM7 [Direct mapping]
Pre-mRNA-splicing factor SLU7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 124 aa
14.2 kDa 		No 0
SLU7-004
ENSP00000428943
ENST00000521826
E5RK41 [Direct mapping]
Pre-mRNA-splicing factor SLU7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0008270 [zinc ion binding]
Show all
 143 aa
16.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.