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Cancer tissues showed weak to moderate cytoplasmic staining with additional nuclear positivity in several tissues. Occasional cases of gliomas, carcinoid, endometrial, cervical and testicular cancers were strongly stained. Several cases of lung and skin cancers were negative.
Most of the cancer tissues showed weak to moderate cytoplasmic positivity. Prostate cancers along with several cases of ovarian, skin, urothelial, renal and stomach cancers were negative.
GENE INFORMATION
Gene name
CAMLG (HGNC Symbol)
Synonyms
CAML, GET2
Description
Calcium modulating ligand (HGNC Symbol)
Entrez gene summary
The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]
