Fields »
ABOUT
HELP
BLOG
KCNK5

GENERAL INFORMATION

Gene name

 KCNK5

Gene description

 Potassium channel, two pore domain subfamily K, member 5

Protein class

 Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (small intestine)
GTEx:Mixed
FANTOM5:Tissue enhanced (small intestine, gallbladder)

Protein evidence

 Evidence at protein level

Protein expression

 Low expression in subset of renal tubules and rare cytoplasmic expression in subsets of immune cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA059148
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine, gallbladder)

GENE INFORMATION

Gene name

 KCNK5 (HGNC Symbol)

Synonyms

 K2p5.1, TASK-2

Description

 Potassium channel, two pore domain subfamily K, member 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p21.2

Chromosome location (bp)

 39188973 - 39229450

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164626 (version 83.38)

Entrez gene

 8645

UniProt

 O95279 (UniProt - Evidence at protein level)

neXtProt

 NX_O95279

Antibodypedia

 KCNK5 antibodies

PROTEIN BROWSER
KCNK5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNK5-001
ENSP00000352527
ENST00000359534
O95279 [Direct mapping]
Potassium channel subfamily K member 5
A0A024RD32 [Target identity:100%; Query identity:100%]
Potassium channel, subfamily K, member 5, isoform CRA_a
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Two-P Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005249 [voltage-gated potassium channel activity]
GO:0005267 [potassium channel activity]
GO:0005887 [integral component of plasma membrane]
GO:0006813 [potassium ion transport]
GO:0007588 [excretion]
GO:0022841 [potassium ion leak channel activity]
GO:0030322 [stabilization of membrane potential]
GO:0034765 [regulation of ion transmembrane transport]
GO:0071804 [cellular potassium ion transport]
GO:0071805 [potassium ion transmembrane transport]
Show all
 499 aa
55.1 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.