Cell atlas - SP8 - The Human Protein Atlas

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SP8

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	SP8
Gene description	Sp8 transcription factor
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus.
RNA cell category	Cell line enhanced (PC-3, NTERA-2, HUVEC TERT2)
Protein evidence	Evidence at transcript level
Main location	Localized to the Nucleus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA054006
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (PC-3, NTERA-2, HUVEC TERT2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus.

Main location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA054006	CACO-2	No staining
	HPA054006	PC-3	Nucleus
	HPA054006	U-2 OS	No staining

GENE INFORMATION
Gene name	SP8
Synonyms
Description	Sp8 transcription factor (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an SP family transcription factor that in mouse has been shown to be essential for proper limb development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Chromosome	7
Cytoband	p21.1
Chromosome location (bp)	20782283 - 20786886
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000164651 (version 83.38)
Entrez gene	221833
UniProt	Q8IXZ3 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8IXZ3
Antibodypedia	SP8 antibodies

PROTEIN BROWSER

SP8-001	SP8-002	SP8-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SP8-001 ENSP00000408792 ENST00000418710	Q8IXZ3 [Direct mapping] Transcription factor Sp8 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0009953 [dorsal/ventral pattern formation] GO:0009954 [proximal/distal pattern formation] GO:0030326 [embryonic limb morphogenesis] GO:0046872 [metal ion binding] Show all	508 aa 50.5 kDa	No	0
SP8-002 ENSP00000354482 ENST00000361443	Q8IXZ3 [Direct mapping] Transcription factor Sp8 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	490 aa 48.7 kDa	No	0
SP8-201 ENSP00000483588 ENST00000617581	A0A087X0Q6 [Direct mapping] Sp8 transcription factor, isoform CRA_d; Transcription factor Sp8 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0046872 [metal ion binding] Show all	466 aa 47.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.