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Several cases of urothelial cancers and squamous cell carcinomas along with a few cases of gliomas, endometrial, prostate and testicular cancers showed moderate to strong cytoplasmic positivity. Remaining cancer tissues were negative.
Most squamous cell carcinomas and several cases of urothelial cancers exhibited moderate to strong cytoplasmic immunoreactivity. A few cases of melanomas, endometrial cancers and testicular embryonal cancers showed moderate staining. Cancer cells in general were negative.
Most squamous cells carcinomas and urothelial cancers showed strong cytoplasmic and nuclear immunoreactivity. Moderate to strong positivity was observed in several melanomas, testicular, colorectal and gastric cancers as well as small fractions of cases the most of the remaining cancers. Gliomas, lymphomas, breast, prostate, ovarian, renal and liver cancers were generally negative.
GENE INFORMATION
Gene name
FABP5 (HGNC Symbol)
Synonyms
E-FABP, KFABP, PA-FABP
Description
Fatty acid binding protein 5 (psoriasis-associated) (HGNC Symbol)
Entrez gene summary
This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs may play roles in fatty acid uptake, transport, and metabolism. Polymorphisms in this gene are associated with type 2 diabetes. The human genome contains many pseudogenes similar to this locus.[provided by RefSeq, Feb 2011]
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
