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Weak to moderate cytoplasmic positivity was observed in most malignant cells. Colorectal cancers and several cases of pancreatic and liver cancers displayed strong staining.
GENE INFORMATION
Gene name
CHMP4C (HGNC Symbol)
Synonyms
MGC22825, Shax3, VPS32C
Description
Charged multivesicular body protein 4C (HGNC Symbol)
Entrez gene summary
CHMP4C belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]