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DEFA6

GENERAL INFORMATION

Gene name

 DEFA6

Gene description

 Defensin, alpha 6, Paneth cell-specific

Protein class

 Plasma proteins
Predicted secreted proteins
Transporters

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (small intestine, duodenum)
GTEx:Tissue enriched (small intestine)
FANTOM5:Group enriched (small intestine, colon)

Protein evidence

 Evidence at protein level

Protein expression

 Expression of paneth cells in intestinal tract

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA019462
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, duodenum)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, colon)

GENE INFORMATION

Gene name

 DEFA6 (HGNC Symbol)

Synonyms

 DEF6, HD-6

Description

 Defensin, alpha 6, Paneth cell-specific (HGNC Symbol)

Entrez gene summary

 Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 6, is highly expressed in the secretory granules of Paneth cells of the small intestine, and likely plays a role in host defense of human bowel. [provided by RefSeq, Oct 2014]

Chromosome

 8

Cytoband

 p23.1

Chromosome location (bp)

 6924693 - 6926076

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164822 (version 83.38)

Entrez gene

 1671

UniProt

 Q01524 (UniProt - Evidence at protein level)

neXtProt

 NX_Q01524

Antibodypedia

 DEFA6 antibodies

PROTEIN BROWSER
DEFA6-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DEFA6-001
ENSP00000297436
ENST00000297436
Q01524 [Direct mapping]
Defensin-6
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Transporters
   Transporter channels and pores
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005796 [Golgi lumen]
GO:0006952 [defense response]
GO:0019731 [antibacterial humoral response]
GO:0031640 [killing of cells of other organism]
GO:0045087 [innate immune response]
GO:0050832 [defense response to fungus]
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 100 aa
11 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.