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A single case of renal cancer along with a few basal cell carcinomas of skin showed strong cytoplasmic and nuclear staining. Remaining cancers were negative.
Malignant cells were generally negative. A few basal cell carcinomas, which showed focal showed strong cytoplasmic and nuclear positivity.
GENE INFORMATION
Gene name
CA3 (HGNC Symbol)
Synonyms
CAIII, Car3
Description
Carbonic anhydrase III (HGNC Symbol)
Entrez gene summary
Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encodes carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. The gene spans 10.3 kb and contains seven exons and six introns. [provided by RefSeq, Oct 2008]
P07451 [Direct mapping] Carbonic anhydrase 3 V9HWA3 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein Li 167mP
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Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
