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Most cancer tissues showed moderate cytoplasmic staining. A few cases of liver cancers were strongly stained. Gliomas and lymphomas were in general negative.
GENE INFORMATION
Gene name
INTS1 (HGNC Symbol)
Synonyms
DKFZp586J0619, INT1, KIAA1440, NET28
Description
Integrator complex subunit 1 (HGNC Symbol)
Entrez gene summary
INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]