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SLC4A2

GENERAL INFORMATION

Gene name

 SLC4A2

Gene description

 Solute carrier family 4 (anion exchanger), member 2

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic and membranous expression, highly abundant in parietal cells in stomach.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA019339
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SLC4A2 (HGNC Symbol)

Synonyms

 AE2, BND3L, EPB3L1, HKB3, NBND3

Description

 Solute carrier family 4 (anion exchanger), member 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 7

Cytoband

 q36.1

Chromosome location (bp)

 151057210 - 151076527

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164889 (version 83.38)

Entrez gene

 6522

UniProt

 P04920 (UniProt - Evidence at protein level)

neXtProt

 NX_P04920

Antibodypedia

 SLC4A2 antibodies

PROTEIN BROWSER
SLC4A2-001
SLC4A2-002
SLC4A2-004
SLC4A2-005
SLC4A2-007
SLC4A2-009
SLC4A2-010
SLC4A2-011
SLC4A2-012
SLC4A2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC4A2-001
ENSP00000405600
ENST00000413384
P04920 [Direct mapping]
Anion exchange protein 2
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 1241 aa
137 kDa 		No >9
SLC4A2-002
ENSP00000419412
ENST00000485713
P04920 [Direct mapping]
Anion exchange protein 2
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006820 [anion transport]
GO:0007283 [spermatogenesis]
GO:0008509 [anion transmembrane transporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019899 [enzyme binding]
GO:0048565 [digestive tract development]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 1241 aa
137 kDa 		No >9
SLC4A2-004
ENSP00000376571
ENST00000392826
P04920 [Direct mapping]
Anion exchange protein 2
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 1232 aa
136.2 kDa 		No >9
SLC4A2-005
ENSP00000419164
ENST00000461735
P04920 [Direct mapping]
Anion exchange protein 2
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 1227 aa
135.6 kDa 		No >9
SLC4A2-007
ENSP00000417808
ENST00000483786
C9J722 [Direct mapping]
Anion exchange protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005452 [inorganic anion exchanger activity]
GO:0005887 [integral component of plasma membrane]
GO:0015701 [bicarbonate transport]
GO:0051453 [regulation of intracellular pH]
GO:1902476 [chloride transmembrane transport]
Show all
 145 aa
15.9 kDa 		No 0
SLC4A2-009
ENSP00000418114
ENST00000490898
C9J9M9 [Direct mapping]
Anion exchange protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005452 [inorganic anion exchanger activity]
GO:0005887 [integral component of plasma membrane]
GO:0015701 [bicarbonate transport]
GO:0051453 [regulation of intracellular pH]
GO:1902476 [chloride transmembrane transport]
Show all
 169 aa
18.6 kDa 		No 0
SLC4A2-010
ENSP00000419379
ENST00000482950
C9JVC2 [Direct mapping]
Anion exchange protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005452 [inorganic anion exchanger activity]
GO:0005887 [integral component of plasma membrane]
GO:0015701 [bicarbonate transport]
GO:0051453 [regulation of intracellular pH]
GO:1902476 [chloride transmembrane transport]
Show all
 127 aa
14.1 kDa 		No 0
SLC4A2-011
ENSP00000418584
ENST00000463414
C9J035 [Direct mapping]
Anion exchange protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005452 [inorganic anion exchanger activity]
GO:0005887 [integral component of plasma membrane]
GO:0015701 [bicarbonate transport]
GO:0051453 [regulation of intracellular pH]
GO:1902476 [chloride transmembrane transport]
Show all
 151 aa
16.5 kDa 		No 0
SLC4A2-012
ENSP00000417221
ENST00000488420
C9J459 [Direct mapping]
Anion exchange protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005452 [inorganic anion exchanger activity]
GO:0005887 [integral component of plasma membrane]
GO:0015701 [bicarbonate transport]
GO:0051453 [regulation of intracellular pH]
GO:1902476 [chloride transmembrane transport]
Show all
 70 aa
7.6 kDa 		No 0
SLC4A2-201
ENSP00000311402
ENST00000310317
J3KNG9 [Direct mapping]
Anion exchange protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0051453 [regulation of intracellular pH]
GO:1902476 [chloride transmembrane transport]
Show all
 1159 aa
127.6 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.