Expression of COX6C in cancer - Summary

CANCER ATLAS

Gene description

Cytochrome c oxidase subunit VIc

Protein class

Cancer-related genes, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA014295	CAB016244

GENE INFORMATION
Gene name	COX6C
Synonyms
Description	Cytochrome c oxidase subunit VIc (HGNC Symbol)
Entrez gene summary	Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes 16p12. [provided by RefSeq, Jul 2010]
Chromosome	8
Cytoband	q22.2
Chromosome location (bp)	99873200 - 99894062
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164919 (version 83.38)
Entrez gene	1345
UniProt	P09669 (UniProt - Evidence at protein level)
neXtProt	NX_P09669
Antibodypedia	COX6C antibodies

PROTEIN BROWSER

COX6C-001	COX6C-002	COX6C-003	COX6C-004	COX6C-005	COX6C-006	COX6C-007	COX6C-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COX6C-001 ENSP00000428895 ENST00000520468	P09669 [Direct mapping] Cytochrome c oxidase subunit 6C A0A024R9B7 [Target identity:100%; Query identity:100%] Cytochrome c oxidase subunit VIc, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004129 [cytochrome-c oxidase activity] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006091 [generation of precursor metabolites and energy] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0010467 [gene expression] GO:0016021 [integral component of membrane] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:1902600 [hydrogen ion transmembrane transport] Show all	75 aa 8.8 kDa	No	1
COX6C-002 ENSP00000429755 ENST00000518171	P09669 [Direct mapping] Cytochrome c oxidase subunit 6C A0A024R9B7 [Target identity:100%; Query identity:100%] Cytochrome c oxidase subunit VIc, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004129 [cytochrome-c oxidase activity] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006091 [generation of precursor metabolites and energy] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0010467 [gene expression] GO:0016021 [integral component of membrane] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:1902600 [hydrogen ion transmembrane transport] Show all	75 aa 8.8 kDa	No	1
COX6C-003 ENSP00000297564 ENST00000297564	P09669 [Direct mapping] Cytochrome c oxidase subunit 6C A0A024R9B7 [Target identity:100%; Query identity:100%] Cytochrome c oxidase subunit VIc, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004129 [cytochrome-c oxidase activity] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006091 [generation of precursor metabolites and energy] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0010467 [gene expression] GO:0016021 [integral component of membrane] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:1902600 [hydrogen ion transmembrane transport] Show all	75 aa 8.8 kDa	No	1
COX6C-004 ENSP00000429707 ENST00000523016	P09669 [Direct mapping] Cytochrome c oxidase subunit 6C A0A024R9B7 [Target identity:100%; Query identity:100%] Cytochrome c oxidase subunit VIc, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004129 [cytochrome-c oxidase activity] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006091 [generation of precursor metabolites and energy] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0010467 [gene expression] GO:0016021 [integral component of membrane] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:1902600 [hydrogen ion transmembrane transport] Show all	75 aa 8.8 kDa	No	1
COX6C-005 ENSP00000429714 ENST00000517682	P09669 [Direct mapping] Cytochrome c oxidase subunit 6C A0A024R9B7 [Target identity:100%; Query identity:100%] Cytochrome c oxidase subunit VIc, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004129 [cytochrome-c oxidase activity] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006091 [generation of precursor metabolites and energy] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0010467 [gene expression] GO:0016021 [integral component of membrane] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:1902600 [hydrogen ion transmembrane transport] Show all	75 aa 8.8 kDa	No	1
COX6C-006 ENSP00000428965 ENST00000522940	P09669 [Direct mapping] Cytochrome c oxidase subunit 6C A0A024R9B7 [Target identity:100%; Query identity:100%] Cytochrome c oxidase subunit VIc, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004129 [cytochrome-c oxidase activity] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006091 [generation of precursor metabolites and energy] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0010467 [gene expression] GO:0016021 [integral component of membrane] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:1902600 [hydrogen ion transmembrane transport] Show all	75 aa 8.8 kDa	No	1
COX6C-007 ENSP00000428150 ENST00000520271	P09669 [Direct mapping] Cytochrome c oxidase subunit 6C A0A024R9B7 [Target identity:100%; Query identity:100%] Cytochrome c oxidase subunit VIc, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004129 [cytochrome-c oxidase activity] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006091 [generation of precursor metabolites and energy] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0010467 [gene expression] GO:0016021 [integral component of membrane] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:1902600 [hydrogen ion transmembrane transport] Show all	75 aa 8.8 kDa	No	1
COX6C-008 ENSP00000429410 ENST00000524245	P09669 [Direct mapping] Cytochrome c oxidase subunit 6C A0A024R9B7 [Target identity:100%; Query identity:100%] Cytochrome c oxidase subunit VIc, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004129 [cytochrome-c oxidase activity] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006091 [generation of precursor metabolites and energy] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0010467 [gene expression] GO:0016021 [integral component of membrane] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:1902600 [hydrogen ion transmembrane transport] Show all	75 aa 8.8 kDa	No	1