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OSR2

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GENERAL INFORMATION

Gene name

 OSR2

Gene description

 Odd-skipped related transciption factor 2

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the plasma membrane. In addition localized to the nucleus.

RNA cell category

 Cell line enhanced (A-431, BJ hTERT+)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (approved)

Additional location

 In addition localized to the Nucleus (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA063486
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (A-431, BJ hTERT+)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the plasma membrane. In addition localized to the nucleus.

Main location

 Plasma membrane (approved)

Additional location

 Nucleus (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA063486 A-431 Nucleus
Plasma membrane
HPA063486 BJ Nucleus
Plasma membrane
HPA063486 U-2 OS Plasma membrane

GENE INFORMATION

Gene name

 OSR2 (HGNC Symbol)

Synonyms

 FLJ90037

Description

 Odd-skipped related transciption factor 2 (HGNC Symbol)

Entrez gene summary

 OSR2 is a mammalian homolog of the Drosophila odd-skipped family of transcription factors (Lan et al., 2004 [PubMed 15175245]).[supplied by OMIM, Mar 2008]

Chromosome

 8

Cytoband

 q22.2

Chromosome location (bp)

 98944403 - 98952104

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164920 (version 83.38)

Entrez gene

 116039

UniProt

 Q8N2R0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N2R0

Antibodypedia

 OSR2 antibodies

PROTEIN BROWSER
OSR2-001
OSR2-002
OSR2-003
OSR2-004
OSR2-006
OSR2-009
OSR2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
OSR2-001
ENSP00000402862
ENST00000435298
Q8N2R0 [Direct mapping]
Protein odd-skipped-related 2
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001656 [metanephros development]
GO:0001823 [mesonephros development]
GO:0002062 [chondrocyte differentiation]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0008284 [positive regulation of cell proliferation]
GO:0009790 [embryo development]
GO:0010628 [positive regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0030501 [positive regulation of bone mineralization]
GO:0033687 [osteoblast proliferation]
GO:0035115 [embryonic forelimb morphogenesis]
GO:0035116 [embryonic hindlimb morphogenesis]
GO:0036023 [embryonic skeletal limb joint morphogenesis]
GO:0042474 [middle ear morphogenesis]
GO:0042476 [odontogenesis]
GO:0042733 [embryonic digit morphogenesis]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048704 [embryonic skeletal system morphogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0060021 [palate development]
GO:0060272 [embryonic skeletal joint morphogenesis]
GO:0060322 [head development]
GO:0060349 [bone morphogenesis]
GO:0061029 [eyelid development in camera-type eye]
GO:0072498 [embryonic skeletal joint development]
Show all
 276 aa
30.6 kDa 		No 0
OSR2-002
ENSP00000297565
ENST00000297565
Q8N2R0 [Direct mapping]
Protein odd-skipped-related 2
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001656 [metanephros development]
GO:0001823 [mesonephros development]
GO:0002062 [chondrocyte differentiation]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0008284 [positive regulation of cell proliferation]
GO:0009790 [embryo development]
GO:0010628 [positive regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0030501 [positive regulation of bone mineralization]
GO:0033687 [osteoblast proliferation]
GO:0035115 [embryonic forelimb morphogenesis]
GO:0035116 [embryonic hindlimb morphogenesis]
GO:0036023 [embryonic skeletal limb joint morphogenesis]
GO:0042474 [middle ear morphogenesis]
GO:0042476 [odontogenesis]
GO:0042733 [embryonic digit morphogenesis]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048704 [embryonic skeletal system morphogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0060021 [palate development]
GO:0060272 [embryonic skeletal joint morphogenesis]
GO:0060322 [head development]
GO:0060349 [bone morphogenesis]
GO:0061029 [eyelid development in camera-type eye]
GO:0072498 [embryonic skeletal joint development]
Show all
 312 aa
35.5 kDa 		No 0
OSR2-003
ENSP00000430780
ENST00000522510
Q8N2R0 [Direct mapping]
Protein odd-skipped-related 2
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001656 [metanephros development]
GO:0001823 [mesonephros development]
GO:0002062 [chondrocyte differentiation]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0008284 [positive regulation of cell proliferation]
GO:0009790 [embryo development]
GO:0010628 [positive regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0030501 [positive regulation of bone mineralization]
GO:0033687 [osteoblast proliferation]
GO:0035115 [embryonic forelimb morphogenesis]
GO:0035116 [embryonic hindlimb morphogenesis]
GO:0036023 [embryonic skeletal limb joint morphogenesis]
GO:0042474 [middle ear morphogenesis]
GO:0042476 [odontogenesis]
GO:0042733 [embryonic digit morphogenesis]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048704 [embryonic skeletal system morphogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0060021 [palate development]
GO:0060272 [embryonic skeletal joint morphogenesis]
GO:0060322 [head development]
GO:0060349 [bone morphogenesis]
GO:0061029 [eyelid development in camera-type eye]
GO:0072498 [embryonic skeletal joint development]
Show all
 312 aa
35.5 kDa 		No 0
OSR2-004
ENSP00000430041
ENST00000523368
E5RH04 [Direct mapping]
Protein odd-skipped-related 2
Show all
Predicted intracellular proteins
Show all
GO:0003676 [nucleic acid binding]
GO:0046872 [metal ion binding]
Show all
 288 aa
32.5 kDa 		No 0
OSR2-006
ENSP00000430074
ENST00000520951
E5RGY8 [Direct mapping]
Protein odd-skipped-related 2
Show all
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   SignalP predicted secreted proteins
Predicted intracellular proteins
Show all
GO:0003676 [nucleic acid binding]
GO:0046872 [metal ion binding]
Show all
 270 aa
30.1 kDa 		No 0
OSR2-009
ENSP00000429910
ENST00000518199
E5RH47 [Direct mapping]
Protein odd-skipped-related 2
Show all
Predicted intracellular proteins
Show all
GO:0003676 [nucleic acid binding]
GO:0046872 [metal ion binding]
Show all
 213 aa
23.8 kDa 		No 0
OSR2-201
ENSP00000414657
ENST00000457907
Q8N2R0 [Direct mapping]
Protein odd-skipped-related 2
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001656 [metanephros development]
GO:0001823 [mesonephros development]
GO:0002062 [chondrocyte differentiation]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0008284 [positive regulation of cell proliferation]
GO:0009790 [embryo development]
GO:0010628 [positive regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0030501 [positive regulation of bone mineralization]
GO:0033687 [osteoblast proliferation]
GO:0035115 [embryonic forelimb morphogenesis]
GO:0035116 [embryonic hindlimb morphogenesis]
GO:0036023 [embryonic skeletal limb joint morphogenesis]
GO:0042474 [middle ear morphogenesis]
GO:0042476 [odontogenesis]
GO:0042733 [embryonic digit morphogenesis]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048704 [embryonic skeletal system morphogenesis]
GO:0048793 [pronephros development]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0060021 [palate development]
GO:0060272 [embryonic skeletal joint morphogenesis]
GO:0060322 [head development]
GO:0060349 [bone morphogenesis]
GO:0061029 [eyelid development in camera-type eye]
GO:0072498 [embryonic skeletal joint development]
GO:2000543 [positive regulation of gastrulation]
Show all
 433 aa
48.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.