Cell atlas - FZD6 - The Human Protein Atlas

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FZD6

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Plasma membrane

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	FZD6
Gene description	Frizzled class receptor 6
Protein class	Disease related genes G-protein coupled receptors Potential drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA017991
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane.

Main location

Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA017991	A-431	Plasma membrane
	HPA017991	U-2 OS	Plasma membrane
	HPA017991	U-251 MG	Plasma membrane

GENE INFORMATION
Gene name	FZD6 (HGNC Symbol)
Synonyms	Hfz6
Description	Frizzled class receptor 6 (HGNC Symbol)
Entrez gene summary	This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]
Chromosome	8
Cytoband	q22.3
Chromosome location (bp)	103298433 - 103332866
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164930 (version 83.38)
Entrez gene	8323
UniProt	O60353 (UniProt - Evidence at protein level)
neXtProt	NX_O60353
Antibodypedia	FZD6 antibodies

PROTEIN BROWSER

FZD6-001	FZD6-002	FZD6-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FZD6-001 ENSP00000429055 ENST00000522566	O60353 [Direct mapping] Frizzled-6 A0A024R9E9 [Target identity:100%; Query identity:100%] Frizzled homolog 6 (Drosophila), isoform CRA_a Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family fz/smo receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0017147 [Wnt-protein binding] GO:0030659 [cytoplasmic vesicle membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0035567 [non-canonical Wnt signaling pathway] GO:0042813 [Wnt-activated receptor activity] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0060070 [canonical Wnt signaling pathway] GO:0090090 [negative regulation of canonical Wnt signaling pathway] Show all	706 aa 79.3 kDa	Yes	7
FZD6-002 ENSP00000429528 ENST00000523739	O60353 [Direct mapping] Frizzled-6 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family fz/smo receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0017147 [Wnt-protein binding] GO:0030659 [cytoplasmic vesicle membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0035567 [non-canonical Wnt signaling pathway] GO:0042813 [Wnt-activated receptor activity] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0060070 [canonical Wnt signaling pathway] GO:0090090 [negative regulation of canonical Wnt signaling pathway] Show all	674 aa 75.6 kDa	No	7
FZD6-201 ENSP00000351605 ENST00000358755	O60353 [Direct mapping] Frizzled-6 A0A024R9E9 [Target identity:100%; Query identity:100%] Frizzled homolog 6 (Drosophila), isoform CRA_a Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family fz/smo receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001736 [establishment of planar polarity] GO:0001843 [neural tube closure] GO:0001942 [hair follicle development] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0016327 [apicolateral plasma membrane] GO:0017147 [Wnt-protein binding] GO:0030168 [platelet activation] GO:0030659 [cytoplasmic vesicle membrane] GO:0030901 [midbrain development] GO:0031625 [ubiquitin protein ligase binding] GO:0033278 [cell proliferation in midbrain] GO:0035567 [non-canonical Wnt signaling pathway] GO:0035880 [embryonic nail plate morphogenesis] GO:0042472 [inner ear morphogenesis] GO:0042813 [Wnt-activated receptor activity] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0045177 [apical part of cell] GO:0060070 [canonical Wnt signaling pathway] GO:0060071 [Wnt signaling pathway, planar cell polarity pathway] GO:0090090 [negative regulation of canonical Wnt signaling pathway] Show all	706 aa 79.3 kDa	Yes	7

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.