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Most melanomas, colorectal, urothelial cancers along with few ovarian, cervical, endometrial, lung, stomach, pancreatic and liver cancers showed weak to moderate cytoplasmic immunoreactivity. A single case of papillary adenocarcinoma of thyroid was strongly stained. Remaining cancer tissues were negative.
This locus encodes a protein that may play a role in the cellular response to arterial injury through involvement in vascular remodeling. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]
Q96CG8 [Direct mapping] Collagen triple helix repeat-containing protein 1
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MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005109 [frizzled binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005581 [collagen trimer] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0016477 [cell migration] GO:0017147 [Wnt-protein binding] GO:0032092 [positive regulation of protein binding] GO:0033690 [positive regulation of osteoblast proliferation] GO:0043932 [ossification involved in bone remodeling] GO:0045669 [positive regulation of osteoblast differentiation] GO:0060071 [Wnt signaling pathway, planar cell polarity pathway] GO:0060122 [inner ear receptor stereocilium organization] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:0090103 [cochlea morphogenesis] GO:0090177 [establishment of planar polarity involved in neural tube closure]
