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PDP1

GENERAL INFORMATION

Gene name

 PDP1

Gene description

 Pyruvate dehyrogenase phosphatase catalytic subunit 1

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 3 antibodies.
HPA018483 , HPA019081 , HPA021152
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PDP1 (HGNC Symbol)

Synonyms

 PDH, PDP, PPM2C

Description

 Pyruvate dehyrogenase phosphatase catalytic subunit 1 (HGNC Symbol)

Entrez gene summary

 Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]

Chromosome

 8

Cytoband

 q22.1

Chromosome location (bp)

 93857807 - 93926066

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164951 (version 83.38)

Entrez gene

 54704

UniProt

 Q9P0J1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9P0J1

Antibodypedia

 PDP1 antibodies

PROTEIN BROWSER
PDP1-001
PDP1-002
PDP1-004
PDP1-006
PDP1-007
PDP1-008
PDP1-009
PDP1-010
PDP1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDP1-001
ENSP00000297598
ENST00000297598
Q9P0J1 [Direct mapping]
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
A0A024R9C0 [Target identity:100%; Query identity:100%]
Protein phosphatase 2C, magnesium-dependent, catalytic subunit, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0004741 [[pyruvate dehydrogenase (lipoamide)] phosphatase activity]
GO:0005515 [protein binding]
GO:0005759 [mitochondrial matrix]
GO:0006090 [pyruvate metabolic process]
GO:0010510 [regulation of acetyl-CoA biosynthetic process from pyruvate]
GO:0035970 [peptidyl-threonine dephosphorylation]
GO:0043169 [cation binding]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
Show all
 537 aa
61.1 kDa 		No 0
PDP1-002
ENSP00000428317
ENST00000520728
Q9P0J1 [Direct mapping]
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
A0A024R9C0 [Target identity:100%; Query identity:100%]
Protein phosphatase 2C, magnesium-dependent, catalytic subunit, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0004741 [[pyruvate dehydrogenase (lipoamide)] phosphatase activity]
GO:0005515 [protein binding]
GO:0005759 [mitochondrial matrix]
GO:0006090 [pyruvate metabolic process]
GO:0010510 [regulation of acetyl-CoA biosynthetic process from pyruvate]
GO:0035970 [peptidyl-threonine dephosphorylation]
GO:0043169 [cation binding]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
Show all
 537 aa
61.1 kDa 		No 0
PDP1-004
ENSP00000430380
ENST00000517764
Q9P0J1 [Direct mapping]
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
A0A024R9C0 [Target identity:100%; Query identity:100%]
Protein phosphatase 2C, magnesium-dependent, catalytic subunit, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0004741 [[pyruvate dehydrogenase (lipoamide)] phosphatase activity]
GO:0005515 [protein binding]
GO:0005759 [mitochondrial matrix]
GO:0006090 [pyruvate metabolic process]
GO:0010510 [regulation of acetyl-CoA biosynthetic process from pyruvate]
GO:0035970 [peptidyl-threonine dephosphorylation]
GO:0043169 [cation binding]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
Show all
 537 aa
61.1 kDa 		No 0
PDP1-006
ENSP00000430931
ENST00000520614
E5RHB9 [Direct mapping]
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0006470 [protein dephosphorylation]
Show all
 72 aa
8.6 kDa 		No 0
PDP1-007
ENSP00000430366
ENST00000518107
E5RFL8 [Direct mapping]
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0006470 [protein dephosphorylation]
Show all
 76 aa
9 kDa 		No 0
PDP1-008
ENSP00000428433
ENST00000518573
E5RIE5 [Direct mapping]
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0006470 [protein dephosphorylation]
Show all
 128 aa
14.9 kDa 		No 0
PDP1-009
ENSP00000430655
ENST00000518827
E5RIV4 [Direct mapping]
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0006470 [protein dephosphorylation]
GO:0043169 [cation binding]
Show all
 232 aa
26.5 kDa 		No 0
PDP1-010
ENSP00000429492
ENST00000521144
E5RI96 [Direct mapping]
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0006470 [protein dephosphorylation]
Show all
 147 aa
16.8 kDa 		No 0
PDP1-201
ENSP00000379503
ENST00000396200
Q9P0J1 [Direct mapping]
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004722 [protein serine/threonine phosphatase activity]
GO:0004724 [magnesium-dependent protein serine/threonine phosphatase activity]
GO:0004741 [[pyruvate dehydrogenase (lipoamide)] phosphatase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006090 [pyruvate metabolic process]
GO:0006470 [protein dephosphorylation]
GO:0010510 [regulation of acetyl-CoA biosynthetic process from pyruvate]
GO:0032403 [protein complex binding]
GO:0035970 [peptidyl-threonine dephosphorylation]
GO:0043169 [cation binding]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
Show all
 562 aa
63.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.