Cell atlas - RPP25L - The Human Protein Atlas

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RPP25L

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	RPP25L
Gene description	Ribonuclease P/MRP 25kDa subunit-like
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported)
Mouse	Localized to the Nucleus, Vesicles in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA052187 , HPA059698
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus.

Main location

Nucleus (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA052187	MCF7	Nucleoplasm
HPA052187	MCF7	Cytosol
HPA052187	PC-3	Nucleoplasm
HPA052187	PC-3	Cytosol
HPA052187	U-2 OS	Nucleoplasm
HPA059698	A549	Nucleus
HPA059698	PC-3	Nucleus
HPA059698	PC-3	Nucleoli
HPA059698	U-2 OS	Nucleus

MOUSE CELLS

Main location

Nucleus, Vesicles

Additional location

Cytosol

Mouse gene

ENSMUSG00000036114 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA052187	NIH 3T3	Nucleus
		Vesicles
		Cytosol

GENE INFORMATION
Gene name	RPP25L (HGNC Symbol)
Synonyms	bA296L22.5, C9orf23, MGC29635
Description	Ribonuclease P/MRP 25kDa subunit-like (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that appears to belong to a family of evolutionarily related proteins (DUF78), that may share one or more domains in common. Members of this family are small archaebacterial proteins with no known function. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	p13.3
Chromosome location (bp)	34610486 - 34612104
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164967 (version 83.38)
Entrez gene	138716
UniProt	Q8N5L8 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N5L8
Antibodypedia	RPP25L antibodies

PROTEIN BROWSER

RPP25L-001	RPP25L-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RPP25L-001 ENSP00000368242 ENST00000378959	Q8N5L8 [Direct mapping] Ribonuclease P protein subunit p25-like protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0044822 [poly(A) RNA binding] Show all	163 aa 17.6 kDa	No	0
RPP25L-002 ENSP00000297613 ENST00000297613	Q8N5L8 [Direct mapping] Ribonuclease P protein subunit p25-like protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0044822 [poly(A) RNA binding] Show all	163 aa 17.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.