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Most cancer tissues displayed weak to moderate cytoplasmic positivity with additional nuclear staining in a few cases. Rare cases of melanomas, ovarian, lung, head and neck cancers exhibited strong staining. Most lymphomas, thyroid and renal cancers along with several cases of other cancer were negative.
DIRAS2 belongs to a distinct branch of the functionally diverse Ras (see HRAS; MIM 190020) superfamily of monomeric GTPases.[supplied by OMIM, Apr 2004]