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Cancer tissues showed weak to moderate cytoplasmic and membranous staining. Few cases of melanomas and prostate cancers displayed additional nuclear/nucleolar positivity. Few cases of urothelial cancers were strongly stained.
GENE INFORMATION
Gene name
ABCA1 (HGNC Symbol)
Synonyms
ABC1, HDLDT1, TGD
Description
ATP-binding cassette, sub-family A (ABC1), member 1 (HGNC Symbol)
Entrez gene summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]