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NFIL3

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GENERAL INFORMATION

Gene name

 NFIL3

Gene description

 Nuclear factor, interleukin 3 regulated

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nuclear bodies.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear bodies (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA003261
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nuclear bodies.

Main location

 Nuclear bodies (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

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Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA003261 A-431 Nuclear bodies
HPA003261 U-2 OS Nuclear bodies
HPA003261 U-251 MG Nuclear bodies

GENE INFORMATION

Gene name

 NFIL3 (HGNC Symbol)

Synonyms

 E4BP4, IL3BP1, NF-IL3A, NFIL3A

Description

 Nuclear factor, interleukin 3 regulated (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses PER1 and PER2 expression and therefore plays a role in the regulation of circadian rhythm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]

Chromosome

 9

Cytoband

 q22.31

Chromosome location (bp)

 91409045 - 91423862

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165030 (version 83.38)

Entrez gene

 4783

UniProt

 Q16649 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16649

Antibodypedia

 NFIL3 antibodies

PROTEIN BROWSER
NFIL3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NFIL3-001
ENSP00000297689
ENST00000297689
Q16649 [Direct mapping]
Nuclear factor interleukin-3-regulated protein
A0A024R241 [Target identity:100%; Query identity:100%]
Nuclear factor interleukin-3-regulated protein
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Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006955 [immune response]
GO:0007623 [circadian rhythm]
GO:0010628 [positive regulation of gene expression]
GO:0043565 [sequence-specific DNA binding]
GO:0071353 [cellular response to interleukin-4]
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 462 aa
51.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.