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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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PRKACG
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

PRKACG

Gene description

Protein kinase, cAMP-dependent, catalytic, gamma

Protein class

Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (testis)
GTEx:Tissue enriched (testis)
FANTOM5:Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in seminiferous ducts in testis.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Supported based on 1 antibody.
CAB004530
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)

GENE INFORMATION

Gene name

PRKACG (HGNC Symbol)

Synonyms

PKACg

Description

Protein kinase, cAMP-dependent, catalytic, gamma (HGNC Symbol)

Entrez gene summary

Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit. [provided by RefSeq, Jul 2008]

Chromosome

9

Cytoband

q21.11

Chromosome location (bp)

69012505 - 69014113

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000165059 (version 83.38)

Entrez gene

5568

UniProt

P22612 (UniProt - Evidence at protein level)

neXtProt

NX_P22612

Antibodypedia

PRKACG antibodies

PROTEIN BROWSER

PRKACG-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PRKACG-001
ENSP00000366488
ENST00000377276
P22612 [Direct mapping]
cAMP-dependent protein kinase catalytic subunit gamma
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003091 [renal water homeostasis]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004691 [cAMP-dependent protein kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006112 [energy reserve metabolic process]
GO:0006468 [protein phosphorylation]
GO:0006833 [water transport]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007283 [spermatogenesis]
GO:0007596 [blood coagulation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008584 [male gonad development]
GO:0019433 [triglyceride catabolic process]
GO:0034199 [activation of protein kinase A activity]
GO:0035556 [intracellular signal transduction]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050796 [regulation of insulin secretion]
GO:0055085 [transmembrane transport]
GO:0071377 [cellular response to glucagon stimulus]
GO:0097546 [ciliary base]
Show all
351 aa
40.4 kDa
No 0

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The Human Protein Atlas project is funded
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