Tissue expression of CPA6 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CPA6
Gene description	Carboxypeptidase A6
Protein class	Disease related genes Enzymes Potential drug targets Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (prostate, rectum)
GTEx:	Tissue enhanced (prostate, vagina)
FANTOM5:	Tissue enhanced (colon, retina)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (prostate, rectum)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (prostate, vagina)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (colon, retina)

GENE INFORMATION
Gene name	CPA6 (HGNC Symbol)
Synonyms	CPAH
Description	Carboxypeptidase A6 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the family of carboxypeptidases, which catalyze the release of C-terminal amino acid, and have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Polymorphic variants and a reciprocal translocation t(6;8)(q26;q13) involving this gene, have been associated with Duane retraction syndrome.[provided by RefSeq, Sep 2010]
Chromosome	8
Cytoband	q13.2
Chromosome location (bp)	67422125 - 67746345
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165078 (version 83.38)
Entrez gene	57094
UniProt	Q8N4T0 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N4T0
Antibodypedia	CPA6 antibodies

PROTEIN BROWSER

CPA6-001	CPA6-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CPA6-001 ENSP00000297770 ENST00000297770	Q8N4T0 [Direct mapping] Carboxypeptidase A6 Show all	Enzymes Peptidases Metallopeptidases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0004180 [carboxypeptidase activity] GO:0004181 [metallocarboxypeptidase activity] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	437 aa 51 kDa	Yes	0
CPA6-003 ENSP00000431112 ENST00000518549	Q8N4T0 [Direct mapping] Carboxypeptidase A6 Show all	Enzymes Peptidases Metallopeptidases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Show all	GO:0004180 [carboxypeptidase activity] GO:0004181 [metallocarboxypeptidase activity] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	315 aa 37.1 kDa	Yes	0