Expression of ALDH1A1 in cancer - Summary

CANCER ATLAS

Gene description

Aldehyde dehydrogenase 1 family, member A1

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Carcinoid

STAINING SUMMARY

HPA002123	CAB020690

GENE INFORMATION
Gene name	ALDH1A1 (HGNC Symbol)
Synonyms	ALDH1, PUMB1, RALDH1
Description	Aldehyde dehydrogenase 1 family, member A1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011]
Chromosome	9
Cytoband	q21.13
Chromosome location (bp)	72900662 - 73080442
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165092 (version 83.38)
Entrez gene	216
UniProt	P00352 (UniProt - Evidence at protein level)
neXtProt	NX_P00352
Antibodypedia	ALDH1A1 antibodies

PROTEIN BROWSER

ALDH1A1-001	ALDH1A1-002	ALDH1A1-005	ALDH1A1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALDH1A1-001 ENSP00000297785 ENST00000297785	P00352 [Direct mapping] Retinal dehydrogenase 1 V9HW83 [Target identity:100%; Query identity:100%] Aldehyde dehydrogenase 1 family, member A1, isoform CRA_a; Epididymis luminal protein 12; Epididymis secretory sperm binding protein Li 53e Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001758 [retinal dehydrogenase activity] GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity] GO:0004029 [aldehyde dehydrogenase (NAD) activity] GO:0005096 [GTPase activator activity] GO:0005497 [androgen binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006069 [ethanol oxidation] GO:0006081 [cellular aldehyde metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0018479 [benzaldehyde dehydrogenase (NAD+) activity] GO:0042572 [retinol metabolic process] GO:0043547 [positive regulation of GTPase activity] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	501 aa 54.9 kDa	No	0
ALDH1A1-002 ENSP00000401361 ENST00000446946	Q5SYQ7 [Direct mapping] Retinal dehydrogenase 1 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001758 [retinal dehydrogenase activity] GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0018479 [benzaldehyde dehydrogenase (NAD+) activity] GO:0055114 [oxidation-reduction process] Show all	203 aa 22.7 kDa	No	0
ALDH1A1-005 ENSP00000366138 ENST00000376939	Q5SYQ9 [Direct mapping] Retinal dehydrogenase 1 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001758 [retinal dehydrogenase activity] GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0018479 [benzaldehyde dehydrogenase (NAD+) activity] GO:0055114 [oxidation-reduction process] Show all	230 aa 25.3 kDa	No	0
ALDH1A1-006 ENSP00000388026 ENST00000419959	Q5SYQ8 [Direct mapping] Retinal dehydrogenase 1 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001758 [retinal dehydrogenase activity] GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0018479 [benzaldehyde dehydrogenase (NAD+) activity] GO:0055114 [oxidation-reduction process] Show all	238 aa 26.1 kDa	No	0