Cell atlas - TRPV6 - The Human Protein Atlas

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TRPV6

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	TRPV6
Gene description	Transient receptor potential cation channel, subfamily V, member 6
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Intracellular,Membrane
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (T-47d, RT4, SK-BR-3, HaCaT)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (T-47d, RT4, SK-BR-3, HaCaT) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	TRPV6 (HGNC Symbol)
Synonyms	CaT1, ECAC2
Description	Transient receptor potential cation channel, subfamily V, member 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a family of multipass membrane proteins that functions as calcium channels. The encoded protein contains N-terminal ankyrin repeats, which are required for channel assembly and regulation. Translation initiation for this protein occurs at a non-AUG start codon that is decoded as methionine. This gene is situated next to a closely related gene for transient receptor potential cation channel subfamily V member 5 (TRPV5). This locus has experienced positive selection in non-African populations, resulting in several non-synonymous codon differences among individuals of different genetic backgrounds. [provided by RefSeq, Feb 2015]
Chromosome	7
Cytoband	q34
Chromosome location (bp)	142871203 - 142885762
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165125 (version 83.38)
Entrez gene	55503
UniProt	Q9H1D0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H1D0
Antibodypedia	TRPV6 antibodies

PROTEIN BROWSER

TRPV6-001	TRPV6-006	TRPV6-007	TRPV6-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRPV6-001 ENSP00000352358 ENST00000359396	Q9H1D0 [Direct mapping] Transient receptor potential cation channel subfamily V member 6 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017158 [regulation of calcium ion-dependent exocytosis] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0070588 [calcium ion transmembrane transport] Show all	765 aa 87.3 kDa	No	6
TRPV6-006 ENSP00000411100 ENST00000436401	C9J9W0 [Direct mapping] Transient receptor potential cation channel subfamily V member 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	122 aa 13.7 kDa	No	3
TRPV6-007 ENSP00000415917 ENST00000431833	C9JHY1 [Direct mapping] Transient receptor potential cation channel subfamily V member 6 Show all	Predicted intracellular proteins Show all	GO:0005262 [calcium channel activity] GO:0016021 [integral component of membrane] GO:0070588 [calcium ion transmembrane transport] Show all	56 aa 6 kDa	No	0
TRPV6-201 ENSP00000479084 ENST00000463646	A0A087WV12 [Direct mapping] Transient receptor potential cation channel subfamily V member 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	526 aa 60.4 kDa	No	6

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.