Expression of PIGA in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Phosphatidylinositol glycan anchor biosynthesis, class A

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA001174

GENE INFORMATION
Gene name	PIGA (HGNC Symbol)
Synonyms	GPI3
Description	Phosphatidylinositol glycan anchor biosynthesis, class A (HGNC Symbol)
Entrez gene summary	This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. A related pseudogene is located on chromosome 12. [provided by RefSeq, Jun 2010]
Chromosome	X
Cytoband	p22.2
Chromosome location (bp)	15319451 - 15335580
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165195 (version 83.38)
Entrez gene	5277
UniProt	P37287 (UniProt - Evidence at protein level)
neXtProt	NX_P37287
Antibodypedia	PIGA antibodies

PROTEIN BROWSER

PIGA-001	PIGA-002	PIGA-003	PIGA-008	PIGA-009	PIGA-010	PIGA-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PIGA-001 ENSP00000369820 ENST00000333590	P37287 [Direct mapping] Phosphatidylinositol N-acetylglucosaminyltransferase subunit A Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000506 [glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006501 [C-terminal protein lipidation] GO:0006506 [GPI anchor biosynthetic process] GO:0008194 [UDP-glycosyltransferase activity] GO:0009893 [positive regulation of metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016254 [preassembly of GPI anchor in ER membrane] GO:0017176 [phosphatidylinositol N-acetylglucosaminyltransferase activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	484 aa 54.1 kDa	No	1
PIGA-002 ENSP00000489528 ENST00000482148		Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006506 [GPI anchor biosynthetic process] Show all	315 aa 35.1 kDa	No	1
PIGA-003 ENSP00000488970 ENST00000475746		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		51 aa 5.7 kDa	No	0
PIGA-008 ENSP00000489540 ENST00000634582		Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		250 aa 28 kDa	No	1
PIGA-009 ENSP00000442653 ENST00000542278	P37287 [Direct mapping] Phosphatidylinositol N-acetylglucosaminyltransferase subunit A Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000506 [glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006501 [C-terminal protein lipidation] GO:0006506 [GPI anchor biosynthetic process] GO:0008194 [UDP-glycosyltransferase activity] GO:0009893 [positive regulation of metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016254 [preassembly of GPI anchor in ER membrane] GO:0017176 [phosphatidylinositol N-acetylglucosaminyltransferase activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	484 aa 54.1 kDa	No	2
PIGA-010 ENSP00000489083 ENST00000634640		Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		150 aa 16.6 kDa	No	1
PIGA-012 ENSP00000489205 ENST00000635543		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006506 [GPI anchor biosynthetic process] Show all	152 aa 17.1 kDa	No	0