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Most cancer tissues displayed distinct membranous staining. Lymphomas as well as a majority of testicular cancers, renal cancers, gliomas and melanomas were negative.
Most cancer tissues showed strong membranous and cytoplasmic positivity. Most cases of gliomas, lymphomas and melanomas as well as testicular cancers were weakly stained or negative.
GENE INFORMATION
Gene name
CLDN3 (HGNC Symbol)
Synonyms
C7orf1, CPE-R2, CPETR2, HRVP1, RVP1
Description
Claudin 3 (HGNC Symbol)
Entrez gene summary
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]
