Cell atlas - NOL6 - The Human Protein Atlas

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NOL6

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria
	Nucleoli
	Nucleus

Human cell
	Mitochondria
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	NOL6
Gene description	Nucleolar protein 6 (RNA-associated)
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus & nucleoli. In addition localized to the mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (validated), Nucleoli (validated)
Additional location	In addition localized to the Mitochondria (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA055891 , HPA061002
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus & nucleoli. In addition localized to the mitochondria.

Main location

Nucleus (validated), Nucleoli (validated)

Additional location

Mitochondria (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA055891	A549	Nucleus
HPA055891	A549	Mitochondria
HPA055891	U-2 OS	Nucleus
HPA055891	U-2 OS	Nucleoli
HPA055891	U-251 MG	Nucleus
HPA055891	U-251 MG	Nucleoli
HPA061002	A549	Nucleus
HPA061002	A549	Nucleoli
HPA061002	HeLa	Nucleus
HPA061002	HeLa	Nucleoli

GENE INFORMATION
Gene name	NOL6 (HGNC Symbol)
Synonyms	bA311H10.1, FLJ21959, MGC14896, MGC14921, MGC20838, Nrap, UTP22
Description	Nucleolar protein 6 (RNA-associated) (HGNC Symbol)
Entrez gene summary	The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	p13.3
Chromosome location (bp)	33461441 - 33473930
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165271 (version 83.38)
Entrez gene	65083
UniProt	Q9H6R4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H6R4
Antibodypedia	NOL6 antibodies

PROTEIN BROWSER

NOL6-002	NOL6-004	NOL6-005	NOL6-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NOL6-002 ENSP00000368783 ENST00000379470	A0A0C4DFX0 [Direct mapping] Nucleolar protein 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006364 [rRNA processing] GO:0006409 [tRNA export from nucleus] GO:0032040 [small-subunit processome] GO:0032545 [CURI complex] GO:0034456 [UTP-C complex] Show all	200 aa 22.2 kDa	No	0
NOL6-004 ENSP00000297990 ENST00000297990	Q9H6R4 [Direct mapping] Nucleolar protein 6 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000794 [condensed nuclear chromosome] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005739 [mitochondrion] GO:0006364 [rRNA processing] GO:0006409 [tRNA export from nucleus] GO:0032040 [small-subunit processome] GO:0032545 [CURI complex] GO:0034456 [UTP-C complex] GO:0044822 [poly(A) RNA binding] Show all	1146 aa 127.6 kDa	No	0
NOL6-005 ENSP00000368784 ENST00000379471	A0A0A0MRW6 [Direct mapping] Nucleolar protein 6 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006364 [rRNA processing] GO:0006409 [tRNA export from nucleus] GO:0032040 [small-subunit processome] GO:0032545 [CURI complex] GO:0034456 [UTP-C complex] Show all	1008 aa 112.2 kDa	No	0
NOL6-006 ENSP00000313978 ENST00000353159	Q9H6R4 [Direct mapping] Nucleolar protein 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000794 [condensed nuclear chromosome] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005739 [mitochondrion] GO:0006364 [rRNA processing] GO:0006409 [tRNA export from nucleus] GO:0032040 [small-subunit processome] GO:0032545 [CURI complex] GO:0034456 [UTP-C complex] GO:0044822 [poly(A) RNA binding] Show all	699 aa 77.6 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.