Fields »
ABOUT
HELP
BLOG
AQP3

GENERAL INFORMATION

Gene name

 AQP3

Gene description

 Aquaporin 3 (Gill blood group)

Protein class

 Blood group antigen proteins
Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Tissue enhanced (esophagus)
FANTOM5:Tissue enhanced (salivary gland, tonsil, esophagus)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in most epithelial and glandular cells, including renal collecting ducts.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA014924
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Esophagus

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (salivary gland, tonsil, esophagus)

GENE INFORMATION

Gene name

 AQP3 (HGNC Symbol)

Synonyms

 GIL

Description

 Aquaporin 3 (Gill blood group) (HGNC Symbol)

Entrez gene summary

 This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. [provided by RefSeq, Aug 2011]

Chromosome

 9

Cytoband

 p13.3

Chromosome location (bp)

 33441154 - 33447611

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165272 (version 83.38)

Entrez gene

 360

UniProt

 Q92482 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q92482

Antibodypedia

 AQP3 antibodies

PROTEIN BROWSER
AQP3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AQP3-001
ENSP00000297991
ENST00000297991
Q92482 [Direct mapping]
Aquaporin-3
Show all
Blood group antigen proteins
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002684 [positive regulation of immune system process]
GO:0003091 [renal water homeostasis]
GO:0005215 [transporter activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006810 [transport]
GO:0006833 [water transport]
GO:0007588 [excretion]
GO:0009992 [cellular water homeostasis]
GO:0015204 [urea transmembrane transporter activity]
GO:0015250 [water channel activity]
GO:0015254 [glycerol channel activity]
GO:0015793 [glycerol transport]
GO:0015840 [urea transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0032526 [response to retinoic acid]
GO:0033280 [response to vitamin D]
GO:0034220 [ion transmembrane transport]
GO:0042476 [odontogenesis]
GO:0045616 [regulation of keratinocyte differentiation]
GO:0051592 [response to calcium ion]
GO:0055085 [transmembrane transport]
GO:0070295 [renal water absorption]
GO:0071918 [urea transmembrane transport]
Show all
 292 aa
31.5 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.