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The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation. [provided by RefSeq, Jul 2008]
P55072 [Direct mapping] Transitional endoplasmic reticulum ATPase V9HW80 [Target identity:100%; Query identity:100%] Epididymis luminal protein 220; Epididymis secretory protein Li 70
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Enzymes ENZYME proteins Hydrolases Transporters Primary Active Transporters Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000502 [proteasome complex] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005811 [lipid particle] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0006302 [double-strand break repair] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006734 [NADH metabolic process] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0008289 [lipid binding] GO:0010918 [positive regulation of mitochondrial membrane potential] GO:0016567 [protein ubiquitination] GO:0016787 [hydrolase activity] GO:0016887 [ATPase activity] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0019079 [viral genome replication] GO:0019903 [protein phosphatase binding] GO:0019904 [protein domain specific binding] GO:0019985 [translesion synthesis] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0030970 [retrograde protein transport, ER to cytosol] GO:0031334 [positive regulation of protein complex assembly] GO:0031593 [polyubiquitin binding] GO:0031625 [ubiquitin protein ligase binding] GO:0032403 [protein complex binding] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0034098 [VCP-NPL4-UFD1 AAA ATPase complex] GO:0034214 [protein hexamerization] GO:0034605 [cellular response to heat] GO:0035800 [deubiquitinase activator activity] GO:0035861 [site of double-strand break] GO:0036435 [K48-linked polyubiquitin binding] GO:0036503 [ERAD pathway] GO:0036513 [Derlin-1 retrotranslocation complex] GO:0042288 [MHC class I protein binding] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043209 [myelin sheath] GO:0043231 [intracellular membrane-bounded organelle] GO:0043234 [protein complex] GO:0043531 [ADP binding] GO:0044389 [ubiquitin-like protein ligase binding] GO:0044822 [poly(A) RNA binding] GO:0045184 [establishment of protein localization] GO:0045732 [positive regulation of protein catabolic process] GO:0046034 [ATP metabolic process] GO:0048471 [perinuclear region of cytoplasm] GO:0051260 [protein homooligomerization] GO:0070062 [extracellular exosome] GO:0070842 [aggresome assembly] GO:0070987 [error-free translesion synthesis] GO:0071712 [ER-associated misfolded protein catabolic process] GO:0072389 [flavin adenine dinucleotide catabolic process] GO:1903006 [positive regulation of protein K63-linked deubiquitination] GO:1903007 [positive regulation of Lys63-specific deubiquitinase activity] GO:1903715 [regulation of aerobic respiration] GO:1903862 [positive regulation of oxidative phosphorylation] GO:1904288 [BAT3 complex binding] GO:1990381 [ubiquitin-specific protease binding] GO:1990730 [VCP-NSFL1C complex] GO:2001171 [positive regulation of ATP biosynthetic process]